N-glycan mannose trimming of Spike

Stable Identifier
R-HSA-9696807
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
endoplasmic reticulum lumen
ReviewStatus
5/5
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N-glycan mannose trimming of Spike
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Except for position 234, all Man(9)-N-glycan modifications on SARS-Cov-2 Spike are further trimmed to yield high-mannose N-glycan groups containing 5-8 mannose sugars. This reaction is mainly catalyzed by human MAN1B1 glycosdase (Watanabe et al, 2020; Avezov et al, 2008).
Literature References
PubMed ID Title Journal Year
32366695 Site-specific glycan analysis of the SARS-CoV-2 spike

Watanabe, Y, Allen, JD, Wrapp, D, McLellan, JS, Crispin, M

Science 2020
Participants
Input
Output
Participates
as an event of
Catalyst Activity

mannosyl-oligosaccharide 1,2-alpha-mannosidase activity of MAN1B1,EDEM2 [endoplasmic reticulum quality control compartment]

Physical Entity
MAN1B1,EDEM2 [endoplasmic reticulum quality control compartment] (Homo sapiens)
Activity
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity (GO:0004571)
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Cross References
Mondo
Authored
Stephan, R  (2020-07-22)
Reviewed
Acencio, ML  (2020-09-09)
Created
Stephan, R  (2020-07-30)
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