N-glycan mannose trimming of Spike

Stable Identifier
R-HSA-9696807
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
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Except for position 234, all Man(9)-N-glycan modifications on SARS-Cov-2 Spike are further trimmed to yield high-mannose N-glycan groups containing 5-8 mannose sugars. This reaction is mainly catalyzed by human MAN1B1 glycosdase (Watanabe et al, 2020; Avezov et al, 2008).

Literature References
PubMed ID Title Journal Year
32366695 Site-specific glycan analysis of the SARS-CoV-2 spike

Watanabe, Y, Allen, JD, Wrapp, D, McLellan, JS, Crispin, M

Science 2020
Participants
Participates
Catalyst Activity

mannosyl-oligosaccharide 1,2-alpha-mannosidase activity of MAN1B1,EDEM2 [endoplasmic reticulum quality control compartment]

Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Reviewed
Created
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