Reactome | FLT3 binds type I TKI

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FLT3 binds type I TKI Show undefined attributes

authored	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9695826] Rothfels, Karen, 2020-07-15
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9695828
disease	[Disease:1500689] cancer
diseaseReaction	[FailedReaction:R-HSA-9702570] KW2449-resistant FLT3 mutants don't bind KW2449 - Homo sapiens [FailedReaction:R-HSA-9702601] midostaurin-resistant FLT3 mutants don't bind midostaurin - Homo sapiens [FailedReaction:R-HSA-9703008] tamatinib-resistant FLT3 mutants don't bind tamatinib - Homo sapiens [FailedReaction:R-HSA-9702593] lestaurtinib-resistant FLT3 mutants don't bind lestaurtinib - Homo sapiens [FailedReaction:R-HSA-9702589] gilteritinib-resistant FLT3 mutants don't bind gilteritinib - Homo sapiens [FailedReaction:R-HSA-9702578] semaxanib-resistant FLT3 mutants don't bind semaxanib - Homo sapiens [FailedReaction:R-HSA-9702997] linafinib-resistant FLT3 mutants don't bind linifanib - Homo sapiens [FailedReaction:R-HSA-9702583] crenolanib-resistant FLT3 mutants don't bind crenolanib - Homo sapiens [Reaction:R-HSA-9702508] FLT mutants bind type I TKIs - Homo sapiens
displayName	FLT3 binds type I TKI
edited	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
eventOf	[Pathway:R-HSA-9607240] FLT3 Signaling - Homo sapiens
input	[Complex:R-HSA-6786754] FLT3LG dimer:FLT3 [plasma membrane] [DefinedSet:R-ALL-9695790] type I FLT3-binding TKIs [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9695653] FLT3 Inhibitors in Acute Myeloid Leukemia: Current Status and Future Directions [LiteratureReference:9695671] Molecular targeting in acute myeloid leukemia [LiteratureReference:9671447] Structural and clinical consequences of activation loop mutations in class III receptor tyrosine kinases
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	FLT3 binds type I TKI
output	[Complex:R-HSA-9695796] FLT3LG dimer:FLT3:FLT3-binding type I TKIs [plasma membrane]
releaseDate	2020-12-08
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9706568] Kazi, Julhash U, 2020-11-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9695828
summation	[Summation:9695827] FLT3 can be bound and inhibited by class I tyrosine kinase i...

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[Pathway:R-HSA-9607240] FLT3 Signaling

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