FLT3 binds type I TKI

Stable Identifier
R-HSA-9695828
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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FLT3 binds type I TKI
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FLT3 can be bound and inhibited by class I tyrosine kinase inhibitors including sunitinib, lesaurtinib, crenolanib, gilteritinib and midostaurin, among others. Type I inhibitors bind in the ATP-binding site of the active conformation and prevent activation of the kinase (reviewed in Larrosa-Garcia and Baer, 2017; Lim et al, 2017; Klug et al, 2018).
Literature References
PubMed ID Title Journal Year
28576946 FLT3 Inhibitors in Acute Myeloid Leukemia: Current Status and Future Directions

Baer, MR, Larrosa-Garcia, M

Mol. Cancer Ther. 2017
29964125 Structural and clinical consequences of activation loop mutations in class III receptor tyrosine kinases

Heinrich, MC, Kent, JD, Klug, LR

Pharmacol. Ther. 2018
28851395 Molecular targeting in acute myeloid leukemia

Dubielecka, PM, Lim, SH, Raghunathan, VM

J Transl Med 2017
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Rothfels, K  (2020-11-06)
Reviewed
Kazi, JU  (2020-11-06)
Created
Rothfels, K  (2020-07-15)
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