FLT3 can be bound and inhibited by class I tyrosine kinase inhibitors including sunitinib, lesaurtinib, crenolanib, gilteritinib and midostaurin, among others. Type I inhibitors bind in the ATP-binding site of the active conformation and prevent activation of the kinase (reviewed in Larrosa-Garcia and Baer, 2017; Lim et al, 2017; Klug et al, 2018).
Klug, LR, Kent, JD, Heinrich, MC
Larrosa-Garcia, M, Baer, MR
Lim, SH, Dubielecka, PM, Raghunathan, VM
© 2021 Reactome