FLT3 can be bound and inhibited by class I tyrosine kinase inhibitors including sunitinib, lesaurtinib, crenolanib, gilteritinib and midostaurin, among others. Type I inhibitors bind in the ATP-binding site of the active conformation and prevent activation of the kinase (reviewed in Larrosa-Garcia and Baer, 2017; Lim et al, 2017; Klug et al, 2018).
Baer, MR, Larrosa-Garcia, M
Heinrich, MC, Kent, JD, Klug, LR
Dubielecka, PM, Lim, SH, Raghunathan, VM
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