Reactome | type I FLT3-binding TKIs [cytosol]

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type I FLT3-binding TKIs [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-9702642] type I TKI-sensitive FLT3 mutants:type I TKIs [plasma membrane] - Homo sapiens [Complex:R-BTA-9695796] FLT3LG dimer:FLT3:FLT3-binding type I TKIs [plasma membrane] - Bos taurus
consumedByEvent	[Reaction:R-HSA-9702508] FLT mutants bind type I TKIs - Homo sapiens [Reaction:R-HSA-9695828] FLT3 binds type I TKI - Homo sapiens
created	[InstanceEdit:9695787] Rothfels, Karen, 2020-07-15
dbId	9695790
displayName	type I FLT3-binding TKIs [cytosol]
hasMember	[ChemicalDrug:R-ALL-9674072] crenolanib [cytosol] [ChemicalDrug:R-ALL-2038921] midostaurin [cytosol] [ChemicalDrug:R-ALL-9695700] gilteritinib [cytosol] [ChemicalDrug:R-ALL-9695703] lestaurtinib [cytosol] [ChemicalDrug:R-ALL-9699412] semaxanib [cytosol] [ChemicalDrug:R-ALL-9699411] KW-2449 [cytosol] [ChemicalDrug:R-ALL-9702979] linifanib [cytosol] [ChemicalDrug:R-ALL-9702985] tamatinib [cytosol] [ChemicalDrug:R-ALL-9702989] TTT-3002 [cytosol]
inDisease	false
literatureReference	[LiteratureReference:9691830] SU5416 and SU5614 inhibit kinase activity of wild-type and mutant FLT3 receptor tyrosine kinase [LiteratureReference:9699345] Mutations of FLT3/ITD confer resistance to multiple tyrosine kinase inhibitors [LiteratureReference:9699248] Crenolanib is a potent inhibitor of FLT3 with activity against resistance-conferring point mutants [LiteratureReference:9674068] The FLT3 and PDGFR inhibitor crenolanib is a substrate of the multidrug resistance protein ABCB1 but does not inhibit transport function at pharmacologically relevant concentrations
maxDepth	2
modified	[InstanceEdit:9703028] Rothfels, Karen, 2020-10-03
name	type I FLT3-binding TKIs
schemaClass	DefinedSet
stId	R-ALL-9695790
updateTrackers	[UpdateTracker:9901854] Update Tracker - [DefinedSet:9695790] type I FLT3-binding TKIs [cytosol] - v75:[addLiteratureReference, add_removeHasMember, modifyName]

Referrals

(updatedInstance)	[UpdateTracker:9901854] Update Tracker - [DefinedSet:9695790] type I FLT3-binding TKIs [cytosol] - v75:[addLiteratureReference, add_removeHasMember, modifyName]
(hasComponent)	[Complex:R-HSA-9702642] type I TKI-sensitive FLT3 mutants:type I TKIs [plasma membrane] [Complex:R-BTA-9695796] FLT3LG dimer:FLT3:FLT3-binding type I TKIs [plasma membrane] [Complex:R-CFA-9695796] FLT3LG dimer:FLT3:FLT3-binding type I TKIs [plasma membrane] [Complex:R-MMU-9695796] FLT3LG dimer:FLT3:FLT3-binding type I TKIs [plasma membrane] [Complex:R-XTR-9695796] FLT3LG dimer:FLT3:FLT3-binding type I TKIs [plasma membrane] [Complex:R-SSC-9695796] FLT3LG dimer:FLT3:FLT3-binding type I TKIs [plasma membrane] [Complex:R-HSA-9695796] FLT3LG dimer:FLT3:FLT3-binding type I TKIs [plasma membrane]
(input)	[Reaction:R-HSA-9702508] FLT mutants bind type I TKIs [Reaction:R-HSA-9695828] FLT3 binds type I TKI
(activeUnit)	[NegativeRegulation:9695849] Negative regulation by 'FLT3LG dimer:FLT3:FLT3-binding type I TKIs [plasma membrane]'

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