Reactome | FLT3LG dimer:FLT3 [plasma membrane]

Schema > Complex > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-9695796] FLT3LG dimer:FLT3:FLT3-binding type I TKIs [plasma membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-9695828] FLT3 binds type I TKI - Homo sapiens [Reaction:R-HSA-8854736] FLT3LG dimer:FLT3 binds FLT3 - Homo sapiens
created	[InstanceEdit:6786759] Jupe, Steve, 2015-07-10
dbId	6786754
displayName	FLT3LG dimer:FLT3 [plasma membrane]
hasComponent	[EntityWithAccessionedSequence:R-HSA-6786756] FLT3 [plasma membrane] [Complex:R-HSA-8854740] FLT3LG dimer [extracellular region]
inDisease	false
includedLocation	[Compartment:984] extracellular region
inferredTo	[Complex:R-MMU-6786754] FLT3LG dimer:FLT3 [plasma membrane] - Mus musculus [Complex:R-CFA-6786754] FLT3LG dimer:FLT3 [plasma membrane] - Canis familiaris [Complex:R-BTA-6786754] FLT3LG dimer:FLT3 [plasma membrane] - Bos taurus [Complex:R-SSC-6786754] FLT3LG dimer:FLT3 [plasma membrane] - Sus scrofa [Complex:R-XTR-6786754] FLT3LG dimer:FLT3 [plasma membrane] - Xenopus tropicalis
isChimeric	false
maxDepth	3
modified	[InstanceEdit:8854731] Jupe, Steve, 2016-01-28
name	FLT3LG dimer:FLT3
producedByEvent	[Reaction:R-HSA-6786789] FLT3LG dimer binds FLT3 - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-6786754

(normalEntity)	[EntityFunctionalStatus:9702571] loss_of_function of KW2449-resistant FLT3 mutants [plasma membrane] [EntityFunctionalStatus:9702602] loss_of_function of midostaurin-resistant FLT3 mutants [plasma membrane] [EntityFunctionalStatus:9703005] loss_of_function of tamatinib-resistant FLT3 mutants [plasma membrane] [EntityFunctionalStatus:9702594] loss_of_function of lestaurtinib-resistant FLT3 mutants [plasma membrane] [EntityFunctionalStatus:9702588] loss_of_function of gilteritinib-resistant FLT3 mutants [plasma membrane] [EntityFunctionalStatus:9702575] loss_of_function of semaxanib-resistant FLT3 mutants [plasma membrane] [EntityFunctionalStatus:9702996] loss_of_function of linifanib-resistant FLT3 mutants [plasma membrane] [EntityFunctionalStatus:9702584] loss_of_function of crenolanib-resistant FLT3 mutants [plasma membrane]
(input)	[Reaction:R-HSA-9695828] FLT3 binds type I TKI [Reaction:R-HSA-8854736] FLT3LG dimer:FLT3 binds FLT3
(output)	[Reaction:R-HSA-6786789] FLT3LG dimer binds FLT3
(hasComponent)	[Complex:R-HSA-9695796] FLT3LG dimer:FLT3:FLT3-binding type I TKIs [plasma membrane] [Complex:R-HSA-8854716] FLT3LG dimer:FLT3 dimer [plasma membrane]

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