Fusion and Release of SARS-CoV-2 Nucleocapsid

Stable Identifier
R-HSA-9694689
Type
Reaction [dissociation]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
endocytic vesicle membrane
ReviewStatus
5/5
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Fusion and Release of SARS-CoV-2 Nucleocapsid
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This COVID-19 event has been created by a combination of computational inference (see https://reactome.org/documentation/inferred-events) from SARS-CoV-1 data and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway.

The SARS-CoV-2 nucleocapsid is released from the host cell endosome into the cytosol. Molecular details of this step are not well worked out. Studies of the infection of the human cultured cells with HCoV-229E coronavirus established a requirement for VCP (transitional endoplasmic reticulum ATPase) protein function for release to occur (Wong et al. 2015). A similar requirement for VCP involvement in SARS-CoV-2 nucleocapsid release is inferred here.
Literature References
PubMed ID Title Journal Year
26311884 Genome-Wide Screen Reveals Valosin-Containing Protein Requirement for Coronavirus Exit from Endosomes

Liu, DX, Moreau, D, Wong, HH, Tay, FP, Bard, F, Kumar, P

J. Virol. 2015
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
VCP [cytosol] (Homo sapiens)
Inferred From
Fusion and Release of SARS-CoV-1 Nucleocapsid (Homo sapiens)
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Gillespie, ME  (2020-09-09)
Reviewed
Acencio, ML  (2020-09-09)
Created
Cook, J  (2020-07-07)
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