Reactome | FKBP1A binds tacrolimus

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FKBP1A binds tacrolimus Show undefined attributes

authored	[InstanceEdit:9678968] Jassal, Bijay, 2020-03-23
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9690466] Jassal, Bijay, 2020-06-01
dbId	9690461
definition	Inhibition
displayName	FKBP1A binds tacrolimus
eventOf	[Pathway:R-HSA-2025928] Calcineurin activates NFAT - Homo sapiens [Pathway:R-HSA-9679191] Potential therapeutics for SARS - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-2026007] FKBP1A [cytosol] [ChemicalDrug:R-ALL-9678991] tacrolimus [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9681023] FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics [LiteratureReference:9681032] Rapamycin and FK506 derivative TH2849 could ameliorate neurodegenerative diseases through autophagy with low immunosuppressive effect [LiteratureReference:9690459] Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	FKBP1A binds tacrolimus
orthologousEvent	[Reaction:R-GGA-9690461] FKBP1A binds tacrolimus - Gallus gallus [Reaction:R-SCE-9690461] FKBP1A binds tacrolimus - Saccharomyces cerevisiae [Reaction:R-SPO-9690461] FKBP1A binds tacrolimus - Schizosaccharomyces pombe [Reaction:R-DDI-9690461] FKBP1A binds tacrolimus - Dictyostelium discoideum [Reaction:R-CEL-9690461] FKBP1A binds tacrolimus - Caenorhabditis elegans [Reaction:R-DME-9690461] FKBP1A binds tacrolimus - Drosophila melanogaster [Reaction:R-DRE-9690461] FKBP1A binds tacrolimus - Danio rerio [Reaction:R-SSC-9690461] FKBP1A binds tacrolimus - Sus scrofa [Reaction:R-BTA-9690461] FKBP1A binds tacrolimus - Bos taurus [Reaction:R-CFA-9690461] FKBP1A binds tacrolimus - Canis familiaris [Reaction:R-RNO-9690461] FKBP1A binds tacrolimus - Rattus norvegicus [Reaction:R-MMU-9690461] FKBP1A binds tacrolimus - Mus musculus
output	[Complex:R-HSA-2026019] FKBP1A:tacrolimus [cytosol]
releaseDate	2020-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9688552] Shoichet, Brian, 2020-05-14
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9690461
summation	[Summation:9690463] Tacrolimus (also FK-506 or Fujimycin) is a macrolide compoun...

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