Reactome | FKBP1A binds tacrolimus

FKBP1A binds tacrolimus

Stable Identifier

R-HSA-9690461

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Tacrolimus (also FK-506 or Fujimycin) is a macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to immunophilins. Tacrolimus is an immunosuppressive drug whose main use is after organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. It reduces peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP1A, creating a new complex. This complex inhibits calcineurin (Bierer et al. 1991) which inhibits T-lymphocyte signal transduction and IL-2 transcription (Kino et al. 1987, Ding et al. 2019).

Literature References

PubMed ID	Title	Journal	Year
2445721	FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics Kino, T, Hatanaka, H, Hashimoto, M, Nishiyama, M, Goto, T, Okuhara, M, Kohsaka, M, Aoki, H, Imanaka, H	J. Antibiot.	1987
30294901	Rapamycin and FK506 derivative TH2849 could ameliorate neurodegenerative diseases through autophagy with low immunosuppressive effect Ding, L, Nan, WH, Zhu, XB, Li, XM, Zhou, LY, Chen, HJ, Yu, L, Ullah Khan, F, Zhong, HB, Shi, XJ	CNS Neurosci Ther	2019
1715244	Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes Liu, J, Farmer, JD, Lane, WS, Friedman, J, Weissman, I, Schreiber, SL	Cell	1991