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Entries
Aberrant regulation of mitotic cell cycle due to RB1 defects
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authored
[InstanceEdit:9687445] Orlic-Milacic, Marija, 2020-05-07
created
[InstanceEdit:9687137] Orlic-Milacic, Marija, 2020-05-06
dbId
9687139
disease
[Disease:1500689] cancer
displayName
Aberrant regulation of mitotic cell cycle due to RB1 defects
doi
10.3180/R-HSA-9687139.1
edited
[InstanceEdit:9689368] Orlic-Milacic, Marija, 2020-05-18
eventOf
[Pathway:R-HSA-9675126] Diseases of mitotic cell cycle - Homo sapiens
figure
[Figure:9830293] /figures/ehld/R-HSA-9687139.svg
hasDiagram
true
hasEHLD
true
hasEvent
[Pathway:R-HSA-9659787] Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects - Homo sapiens
[Pathway:R-HSA-9687136] Aberrant regulation of mitotic exit in cancer due to RB1 defects - Homo sapiens
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:9661101] One hit, two hits, three hits, more? Genomic changes in the development of retinoblastoma
[LiteratureReference:9661099] Retinoblastoma
[LiteratureReference:9661104] Two genetic hits (more or less) to cancer
[LiteratureReference:9661098] Comprehensive molecular characterization of urothelial bladder carcinoma
[LiteratureReference:9646957] Integrated genomic analyses of ovarian carcinoma
[LiteratureReference:2206354] Molecular analysis of the retinoblastoma gene in primary ovarian cancer cells
[LiteratureReference:9661095] Analysis of DNA copy number alterations in ovarian serous tumors identifies new molecular genetic changes in low-grade and high-grade carcinomas
[LiteratureReference:9661125] The retinoblastoma tumour suppressor in development and cancer
[LiteratureReference:9661188] Non-canonical functions of the RB protein in cancer
[LiteratureReference:9661157] Structure-function analysis of the retinoblastoma tumor suppressor protein - is the whole a sum of its parts?
[LiteratureReference:9661115] RB1: a prototype tumor suppressor and an enigma
[LiteratureReference:9661152] Coordinated regulation of life and death by RB
[LiteratureReference:9661212] Cellular mechanisms of tumour suppression by the retinoblastoma gene
[LiteratureReference:9661145] RB: mitotic implications of a tumour suppressor
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name
Aberrant regulation of mitotic cell cycle due to RB1 defects
releaseDate
2020-06-10
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9689366] Dick, Frederick Andrew, 2020-05-17
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-9687139
summation
[Summation:9687138] RB1 was the first tumor suppressor gene discovered. Bi-allel...
Referrals
(hasEvent)
[Pathway:R-HSA-9675126] Diseases of mitotic cell cycle
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