Reactome | NS1 binds MLKL

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NS1 binds MLKL Show undefined attributes

authored	[InstanceEdit:9689635] Shamovsky, Veronica, 2020-05-21
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9686330] Shamovsky, Veronica, 2020-04-30
crossReference	[DatabaseIdentifier:12020763] Mondo:0005812
dbId	9686343
disease	[Disease:1660558] influenza
displayName	NS1 binds MLKL
edited	[InstanceEdit:9698642] Shamovsky, Veronica, 2020-08-28
eventOf	[Pathway:R-HSA-9686347] Microbial modulation of RIPK1-mediated regulated necrosis - Homo sapiens [Pathway:R-HSA-168276] NS1 Mediated Effects on Host Pathways - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-5218901] MLKL [cytosol] [Complex:R-FLU-169143] NS1 dimer [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9686325] The NS1 Protein of Influenza A Virus Participates in Necroptosis by Interacting with MLKL and Increasing Its Oligomerization and Membrane Translocation
maxDepth	1
modified	[InstanceEdit:9970989] Shamovsky, Veronica, 2025-11-03
name	NS1 binds MLKL IAV NS1 binds MLKL
output	[Complex:R-HSA-9686346] NS1:MLKL [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-192841] Viral Protein Synthesis - Homo sapiens
relatedSpecies	[Species:9031716] Influenza A virus
releaseDate	2020-09-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9692900] D'Eustachio, Peter, 2020-06-26 [InstanceEdit:9698846] Murphy, James M, 2020-08-28
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9686343
summation	[Summation:9686327] Co-immunoprecipitation assays in influenza A virus (IAV)-inf...

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