Reactome | Microbial modulation of RIPK1-mediated regulated necrosis

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Microbial modulation of RIPK1-mediated regulated necrosis Show undefined attributes

authored	[InstanceEdit:9689635] Shamovsky, Veronica, 2020-05-21
created	[InstanceEdit:9686330] Shamovsky, Veronica, 2020-04-30
crossReference	[DatabaseIdentifier:12819459] BioModels Database:BIOMD0000000407 [DatabaseIdentifier:12020762] Mondo:0005108
dbId	9686347
disease	[Disease:3134792] bacterial infectious disease [Disease:3134794] viral infectious disease
displayName	Microbial modulation of RIPK1-mediated regulated necrosis
edited	[InstanceEdit:9698642] Shamovsky, Veronica, 2020-08-28
eventOf	[Pathway:R-HSA-9693928] Defective RIPK1-mediated regulated necrosis - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-9686345] SARS-CoV-1 3a binds RIPK1:RIPK3 oligomer - Homo sapiens [Polymerisation:R-HSA-9686336] SARS-CoV-1 3a oligomerizes - Homo sapiens [BlackBoxEvent:R-HSA-9686338] SARS-CoV-1 3a binds the lysosomal membrane - Homo sapiens [Reaction:R-HSA-9686343] NS1 binds MLKL - Homo sapiens [Reaction:R-HSA-9687465] HSV1 RIR1 binds RIPK1 - Homo sapiens [Reaction:R-HSA-9687455] HSV1 RIR1 binds RIPK3 - Homo sapiens [Reaction:R-HSA-9687458] HSV1 RIR1 binds CASP8 - Homo sapiens [Reaction:R-HSA-2672196] Viral serpin blocks caspase-8 activity - Homo sapiens [Reaction:R-HSA-9698677] HCMV UL36 binds MLKL - Homo sapiens
isInDisease	true
isInferred	false
lastUpdatedDate	2021-03-24
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	Microbial modulation of RIPK1-mediated regulated necrosis
releaseDate	2020-09-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9692900] D'Eustachio, Peter, 2020-06-26 [InstanceEdit:9698846] Murphy, James M, 2020-08-28
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9686347
summation	[Summation:9693143] Activation of receptor-interacting serine/threonine protein ...
updateTrackers	[UpdateTracker:9776385] Update Tracker - [Pathway:9686347] Microbial modulation of RIPK1-mediated regulated necrosis - v76:[updateContainedRLE] [UpdateTracker:9776512] Update Tracker - [Pathway:9686347] Microbial modulation of RIPK1-mediated regulated necrosis - v75:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9776385] Update Tracker - [Pathway:9686347] Microbial modulation of RIPK1-mediated regulated necrosis - v76:[updateContainedRLE] [UpdateTracker:9776512] Update Tracker - [Pathway:9686347] Microbial modulation of RIPK1-mediated regulated necrosis - v75:[updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-9693928] Defective RIPK1-mediated regulated necrosis