Reactome | Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC)

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Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC) Show undefined attributes

authored	[InstanceEdit:9686443] Orlic-Milacic, Marija, 2020-04-30
created	[InstanceEdit:9683440] Orlic-Milacic, Marija, 2020-04-15
crossReference	[DatabaseIdentifier:12020764] Mondo:0005091
dbId	9683439
disease	[Disease:9678120] severe acute respiratory syndrome
displayName	Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC)
edited	[InstanceEdit:9687600] Orlic-Milacic, Marija, 2020-05-11
eventOf	[Pathway:R-HSA-9679504] Translation of Replicase and Assembly of the Replication Transcription Complex - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-9680812] nsp7 binds nsp8 - Homo sapiens [Reaction:R-HSA-9680811] nsp12 binds nsp7 and nsp8 - Homo sapiens [Reaction:R-HSA-9682544] nsp14 binds nsp10 - Homo sapiens [Reaction:R-HSA-9682258] nsp14 binds nsp12 - Homo sapiens [Reaction:R-HSA-9682626] nsp13 binds nsp12 - Homo sapiens [Reaction:R-HSA-9682718] nsp15 forms a hexamer - Homo sapiens [Reaction:R-HSA-9683393] nsp15 binds nsp8 - Homo sapiens [Reaction:R-HSA-9683429] nsp16 binds nsp10 - Homo sapiens [BlackBoxEvent:R-HSA-9686013] Nsp3:nsp4 binds to nsp6 - Homo sapiens [BlackBoxEvent:R-HSA-9686005] nsp3 binds to nsp7-8 and nsp12-16 - Homo sapiens
isInDisease	true
isInferred	false
lastUpdatedDate	2021-12-08
literatureReference	[LiteratureReference:9679510] Human Coronavirus: Host-Pathogen Interaction [LiteratureReference:9680809] Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors
maxDepth	2
modified	[InstanceEdit:9847082] Weiser, Joel, 2023-10-12
name	Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC)
precedingEvent	[Pathway:R-HSA-9684325] Maturation of replicase proteins - Homo sapiens
relatedSpecies	[Species:9678119] Human SARS coronavirus
releaseDate	2020-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9690206] Acencio, Marcio Luis, Mazein, Alexander, 2020-05-27
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9683439
summation	[Summation:9689352] In a sequence of ten reactions, mature non-structural protei...
updateTrackers	[UpdateTracker:9776708] Update Tracker - [Pathway:9683439] Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC) - v74:[updateContainedRLE] [UpdateTracker:9775440] Update Tracker - [Pathway:9683439] Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC) - v79:[updateContainedRLE]

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(updatedInstance)	[UpdateTracker:9776708] Update Tracker - [Pathway:9683439] Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC) - v74:[updateContainedRLE] [UpdateTracker:9775440] Update Tracker - [Pathway:9683439] Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC) - v79:[updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-9679504] Translation of Replicase and Assembly of the Replication Transcription Complex

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