Reactome | nsp7 binds nsp8

Schema > Reaction > Entries

authored	[InstanceEdit:9686443] Orlic-Milacic, Marija, 2020-04-30
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9680810] Orlic-Milacic, Marija, 2020-03-30
crossReference	[DatabaseIdentifier:12020764] Mondo:0005091
dbId	9680812
disease	[Disease:9678120] severe acute respiratory syndrome
displayName	nsp7 binds nsp8
edited	[InstanceEdit:9687600] Orlic-Milacic, Marija, 2020-05-11
eventOf	[Pathway:R-HSA-9683439] Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC) - Homo sapiens
followingEvent	[Reaction:R-HSA-9680811] nsp12 binds nsp7 and nsp8 - Homo sapiens
input	[DefinedSet:R-COV-9682245] nsp7 [cytosol] [DefinedSet:R-COV-9682241] nsp8 [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9680809] Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors [LiteratureReference:9681142] Insights into SARS-CoV transcription and replication from the structure of the nsp7-nsp8 hexadecamer
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	nsp7 binds nsp8
output	[Complex:R-COV-9680806] nsp7:nsp8 [cytosol]
relatedSpecies	[Species:9678119] Human SARS coronavirus
releaseDate	2020-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9690206] Acencio, Marcio Luis, Mazein, Alexander, 2020-05-27
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9680812
summation	[Summation:9680808] Human SARS coronavirus nonstructural proteins nsp7 and nsp8 ...

(hasEvent)	[Pathway:R-HSA-9683439] Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC)
(precedingEvent)	[Reaction:R-HSA-9680811] nsp12 binds nsp7 and nsp8

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