Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC)

Stable Identifier
R-HSA-9683439
Type
Pathway
Species
Homo sapiens
Related Species
Human SARS coronavirus
ReviewStatus
5/5
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Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC)
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In a sequence of ten reactions, mature non-structural proteins (nsp) generated by cleavage of the SARS-CoV-1 pp1a / pp1ab polyproteins are assembled to form a replication – transcription complex (Fung & Liu 2019; Kirchdoerfer & Ward 2019).
Literature References
PubMed ID Title Journal Year
31138817 Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors

Kirchdoerfer, RN, Ward, AB

Nat Commun 2019
31226023 Human Coronavirus: Host-Pathogen Interaction

Fung, TS, Liu, DX

Annu. Rev. Microbiol. 2019
Participants
Events
Participates
as an event of
Disease
Name Identifier Synonyms
severe acute respiratory syndrome DOID:2945 SARS-CoV infection, SARS
Authored
Orlic-Milacic, M  (2020-04-30)
Reviewed
Acencio, ML  (2020-05-27)
Mazein, A  (2020-05-27)
Created
Orlic-Milacic, M  (2020-04-15)
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