Reactome | nsp12 synthesizes minus strand SARS-CoV-1 genomic RNA complement

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nsp12 synthesizes minus strand SARS-CoV-1 genomic RNA complement Show undefined attributes

authored	[InstanceEdit:9686443] Orlic-Milacic, Marija, 2020-04-30
catalystActivity	[CatalystActivity:9681837] RNA-directed RNA polymerase activity of SARS coronavirus gRNA:RTC:RNA primer [double membrane vesicle viral factory outer membrane]
category	uncertain
compartment	[Compartment:70101] cytosol [Compartment:9684675] double membrane vesicle viral factory outer membrane
created	[InstanceEdit:9681677] Orlic-Milacic, Marija, 2020-04-03
crossReference	[DatabaseIdentifier:12020764] Mondo:0005091
dbId	9681674
disease	[Disease:9678120] severe acute respiratory syndrome
displayName	nsp12 synthesizes minus strand SARS-CoV-1 genomic RNA complement
edited	[InstanceEdit:9687600] Orlic-Milacic, Marija, 2020-05-11
eventOf	[Pathway:R-HSA-9682706] Replication of the SARS-CoV-1 genome - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9682563] nsp12 misincorporates a nucleotide in nascent RNA minus strand - Homo sapiens
input	[SimpleEntity:R-ALL-6806881] NTP [cytosol] [Complex:R-COV-9681663] SARS coronavirus gRNA:RTC:RNA primer [double membrane vesicle viral factory outer membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9681673] Biochemical characterization of a recombinant SARS coronavirus nsp12 RNA-dependent RNA polymerase capable of copying viral RNA templates [LiteratureReference:9682259] One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	nsp12 synthesizes minus strand SARS-CoV-1 genomic RNA complement
output	[SimpleEntity:R-ALL-111294] PPi [cytosol] [Complex:R-COV-9682469] SARS-CoV-1 gRNA:RTC:nascent RNA minus strand [double membrane vesicle viral factory outer membrane]
precedingEvent	[BlackBoxEvent:R-HSA-9681651] nsp8 generates RNA primers - Homo sapiens
regulatedBy	[NegativeRegulation:9687386] Negative regulation by 'SARS coronavirus gRNA:RTC:RNA primer:RTC inhibitors [double membrane vesicle viral factory outer membrane]'
relatedSpecies	[Species:9678119] Human SARS coronavirus
releaseDate	2020-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9690206] Acencio, Marcio Luis, Mazein, Alexander, 2020-05-27
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9681674
summation	[Summation:9681828] Virally encoded RNA-dependent RNA polymerase (nsp12, also kn...

Referrals

(hasEvent)	[Pathway:R-HSA-9682706] Replication of the SARS-CoV-1 genome
(precedingEvent)	[BlackBoxEvent:R-HSA-9682563] nsp12 misincorporates a nucleotide in nascent RNA minus strand

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