Reactome | Biochemical characterization of a recombinant SARS coronavirus nsp12 RNA-dependent RNA polymerase capable of copying viral RNA templates

Schema > LiteratureReference > Entries

Biochemical characterization of a recombinant SARS coronavirus nsp12 RNA-dependent RNA polymerase capable of copying viral RNA templates Show undefined attributes

author	[Person:9681678] Ahn, DG [Person:9681672] Choi, JK [Person:9681675] Taylor, DR [Person:9681679] Oh, JW
created	[InstanceEdit:9681677] Orlic-Milacic, Marija, 2020-04-03
dbId	9681673
displayName	Biochemical characterization of a recombinant SARS coronavirus nsp12 RNA-dependent RNA polymerase capable of copying viral RNA templates
journal	Arch. Virol.
pages	2095-104
pubMedIdentifier	22791111
schemaClass	LiteratureReference
title	Biochemical characterization of a recombinant SARS coronavirus nsp12 RNA-dependent RNA polymerase capable of copying viral RNA templates
url	http://www.ncbi.nlm.nih.gov/pubmed/22791111
volume	157
year	2012

Referrals

(literatureReference)

[Summation:9694405] The cryo-electron microscopy (cryoEM) structure of the SARS-...
[Summation:9694429] After synthesizing the complementary minus RNA of the plus s...
[Summation:9694640] This COVID-19 event has been created by a combination of computational inference (see https://reactome.org/documentation/inferred-events) from SARS-CoV-1 data and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway.

After synthesizing the complementary minus RNA of the plus strand viral genomic RNA, SARS-CoV-1 replication-transcription complex (RTC) associates with the minus strand to initiate plus strand synthesis and to initiate transcription of subgenomic (sg) mRNAs (Ahn et al. 2012).
[Summation:9694744] Virally encoded RNA-dependent RNA polymerase (nsp12, also kn...
[Reaction:R-HSA-9681314] Replication transcription complex binds SARS-CoV-1 genomic RNA
[BlackBoxEvent:R-HSA-9681840] RTC synthesizes SARS-CoV-1 plus strand genomic RNA
[Reaction:R-HSA-9685597] RTC binds SARS-CoV-1 genomic RNA complement (minus strand)
[BlackBoxEvent:R-HSA-9681674] nsp12 synthesizes minus strand SARS-CoV-1 genomic RNA complement

(author)

© 2026 Reactome

Cite Us!