Reactome | KIT N822Y [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

candidateOf	[CandidateSet:R-HSA-9669760] kinase domain KIT mutants [plasma membrane] - Homo sapiens
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9669459] Rothfels, Karen, 2019-12-03
crossReference	[DatabaseIdentifier:12021300] Mondo:0003669 [DatabaseIdentifier:9669335] COSMIC:COSV55387376 [DatabaseIdentifier:9669322] COSMIC:COSM24640
dbId	9669454
disease	[Disease:1500689] cancer [Disease:9669018] testis seminoma [Disease:9630839] acute myeloid leukemia [Disease:9661830] gastrointestinal stromal tumor [Disease:1614289] melanoma
displayName	KIT N822Y [plasma membrane]
endCoordinate	976
hasModifiedResidue	[ReplacedResidue:9669467] L-asparagine 822 replaced with L-tyrosine
inDisease	true
maxDepth	1
memberOf	[CandidateSet:R-HSA-9681384] ripretinib-sensitive KIT mutants [plasma membrane] - Homo sapiens [DefinedSet:R-HSA-9669825] regorafenib sensitive KIT mutants [plasma membrane] - Homo sapiens
name	KIT N822Y Mast/stem cell growth factor receptor precursor KIT_HUMAN c-KIT
referenceEntity	[ReferenceGeneProduct:uniprot:P10721] UniProt:P10721 KIT
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9669454
startCoordinate	26

(hasCandidate)	[CandidateSet:R-HSA-9669760] kinase domain KIT mutants [plasma membrane]
(hasMember)	[DefinedSet:R-HSA-9669825] regorafenib sensitive KIT mutants [plasma membrane] [CandidateSet:R-HSA-9681384] ripretinib-sensitive KIT mutants [plasma membrane]

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