Reactome | COMT binds COMT Inhibitors

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COMT binds COMT Inhibitors Show undefined attributes

authored	[InstanceEdit:9679866] Jassal, Bijay, 2020-03-25
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:9679866] Jassal, Bijay, 2020-03-25
dbId	9679775
definition	Inhibition
displayName	COMT binds COMT Inhibitors
edited	[InstanceEdit:9679866] Jassal, Bijay, 2020-03-25
eventOf	[Pathway:R-HSA-379397] Enzymatic degradation of dopamine by COMT - Homo sapiens [Pathway:R-HSA-9679191] Potential therapeutics for SARS - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-379386] COMT [plasma membrane] [DefinedSet:R-ALL-9679778] COMT inhibitors [extracellular region]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9679855] Kinetics of human soluble and membrane-bound catechol O-methyltransferase: a revised mechanism and description of the thermolabile variant of the enzyme [LiteratureReference:9679824] A fragment-based approach to identifying S-adenosyl-l-methionine -competitive inhibitors of catechol O-methyl transferase (COMT)
maxDepth	1
modified	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
name	COMT binds COMT Inhibitors
orthologousEvent	[Reaction:R-SPO-9679775] COMT binds COMT Inhibitors - Schizosaccharomyces pombe [Reaction:R-GGA-9679775] COMT binds COMT Inhibitors - Gallus gallus [Reaction:R-XTR-9679775] COMT binds COMT Inhibitors - Xenopus tropicalis [Reaction:R-DRE-9679775] COMT binds COMT Inhibitors - Danio rerio [Reaction:R-SSC-9679775] COMT binds COMT Inhibitors - Sus scrofa [Reaction:R-BTA-9679775] COMT binds COMT Inhibitors - Bos taurus [Reaction:R-CFA-9679775] COMT binds COMT Inhibitors - Canis familiaris [Reaction:R-RNO-9679775] COMT binds COMT Inhibitors - Rattus norvegicus [Reaction:R-MMU-9679775] COMT binds COMT Inhibitors - Mus musculus
output	[Complex:R-HSA-9679812] COMT:COMT inhibitors [plasma membrane]
releaseDate	2020-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9688552] Shoichet, Brian, 2020-05-14
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9679775
summation	[Summation:9685414] Catechol-O-methyltransferase (COMT) is one of several enzyme...

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