Reactome | COMT binds COMT Inhibitors

Schema > Reaction > Entries

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:10427439] Wright, Adam, 2024-03-07
dbId	10480973
displayName	COMT binds COMT Inhibitors
eventOf	[Pathway:R-DRE-379397] Enzymatic degradation of dopamine by COMT - Danio rerio
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9679775] COMT binds COMT Inhibitors - Homo sapiens
input	[EntityWithAccessionedSequence:R-DRE-379386] COMT [plasma membrane] [DefinedSet:R-ALL-9679778] COMT inhibitors [extracellular region]
isInDisease	false
isInferred	true
name	COMT binds COMT Inhibitors
output	[Complex:R-DRE-9679812] COMT:COMT inhibitors [plasma membrane]
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-9679775
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DRE-379397] Enzymatic degradation of dopamine by COMT
(inferredTo)	[Reaction:R-HSA-9679775] COMT binds COMT Inhibitors