Reactome | Enzymatic degradation of dopamine by COMT

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Enzymatic degradation of dopamine by COMT Show undefined attributes

authored	[InstanceEdit:374906] Mahajan, SS, 2008-08-05 20:29:44
created	[InstanceEdit:379396] Mahajan, SS, 2008-10-17 21:23:03
dbId	379397
displayName	Enzymatic degradation of dopamine by COMT
edited	[InstanceEdit:447013] Gillespie, ME, 2009-11-19
eventOf	[Pathway:R-HSA-379401] Dopamine clearance from the synaptic cleft - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:12107] dopamine catabolic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-379387] COMT transfers Met to DA to form 3MT - Homo sapiens [Reaction:R-HSA-9679775] COMT binds COMT Inhibitors - Homo sapiens [Reaction:R-HSA-8955010] LRTOMT transfers Met to DA, forming 3MT - Homo sapiens [Reaction:R-HSA-379395] MAOA:FAD deaminates 3MT to HVA - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2020-09-24
literatureReference	[LiteratureReference:379475] Human catechol-O-methyltransferase haplotypes modulate protein expression by altering mRNA secondary structure
maxDepth	2
modified	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
name	Enzymatic degradation of dopamine by COMT
orthologousEvent	[Pathway:R-SPO-379397] Enzymatic degradation of dopamine by COMT - Schizosaccharomyces pombe [Pathway:R-DDI-379397] Enzymatic degradation of dopamine by COMT - Dictyostelium discoideum [Pathway:R-GGA-379397] Enzymatic degradation of dopamine by COMT - Gallus gallus [Pathway:R-XTR-379397] Enzymatic degradation of dopamine by COMT - Xenopus tropicalis [Pathway:R-DRE-379397] Enzymatic degradation of dopamine by COMT - Danio rerio [Pathway:R-SSC-379397] Enzymatic degradation of dopamine by COMT - Sus scrofa [Pathway:R-BTA-379397] Enzymatic degradation of dopamine by COMT - Bos taurus [Pathway:R-CFA-379397] Enzymatic degradation of dopamine by COMT - Canis familiaris [Pathway:R-RNO-379397] Enzymatic degradation of dopamine by COMT - Rattus norvegicus [Pathway:R-MMU-379397] Enzymatic degradation of dopamine by COMT - Mus musculus
precedingEvent	[Reaction:R-HSA-379393] SLC6A3 cotransports DA, Na+, Cl- from extracellular region to cytosol - Homo sapiens
releaseDate	2008-12-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:386898] Restituito, S, 2008-11-27 12:38:49
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-379397
summation	[Summation:379472] Dopamine once taken up by the dopamine transporter from the ...
updateTrackers	[UpdateTracker:9776897] Update Tracker - [Pathway:379397] Enzymatic degradation of dopamine by COMT - v74:[addHasEvent, updateContainedRLE] [UpdateTracker:9781361] Update Tracker - [Pathway:379397] Enzymatic degradation of dopamine by COMT - v61:[updateContainedRLE] [UpdateTracker:9782023] Update Tracker - [Pathway:379397] Enzymatic degradation of dopamine by COMT - v60:[addHasEvent, updateContainedRLE] [UpdateTracker:9777067] Update Tracker - [Pathway:379397] Enzymatic degradation of dopamine by COMT - v73:[updateContainedRLE]

Referrals

(updatedInstance)

[UpdateTracker:9776897] Update Tracker - [Pathway:379397] Enzymatic degradation of dopamine by COMT - v74:[addHasEvent, updateContainedRLE]
[UpdateTracker:9781361] Update Tracker - [Pathway:379397] Enzymatic degradation of dopamine by COMT - v61:[updateContainedRLE]
[UpdateTracker:9782023] Update Tracker - [Pathway:379397] Enzymatic degradation of dopamine by COMT - v60:[addHasEvent, updateContainedRLE]
[UpdateTracker:9777067] Update Tracker - [Pathway:379397] Enzymatic degradation of dopamine by COMT - v73:[updateContainedRLE]

(hasEvent)

[Pathway:R-HSA-379401] Dopamine clearance from the synaptic cleft

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