These compounds are inhibitors of cytochrome P450 3A enzymes...

created [InstanceEdit:9681847] Jassal, Bijay, 2020-04-06
dbId 9681849
displayName These compounds are inhibitors of cytochrome P450 3A enzymes...
modified [InstanceEdit:9684395] Jassal, Bijay, 2020-04-21
schemaClass Summation
text These compounds are inhibitors of cytochrome P450 3A enzymes (von Moltke et al. 1999, Yeo & Yeo 2001, Xu et al. 2010, Temesgen 2013, Greenblatt & Harmatz 2015). Cytochrome P450 3A4 (CYP3A4) is the most broadly active drug-metabolizing enzyme in humans. It oxidizes and clears over half of all administered pharmaceuticals due to its promiscuity. By inhibiting CYP3A4, these drugs can enhance bioavailability and prolong the plasma half-life of antiretroviral drugs such as those used to treat HIV infection.
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