JAK2 binds JAK1,2 inhibitors

Stable Identifier
R-HSA-9678561
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Janus Kinase 2 (JAK2) binds and is inhibited by several small molecule drugs (Clark et al. 2014, Fridman et al. 2010, Hanan et al. 2012). The Janus kinases (JAKs) are a family of intracellular tyrosine kinases that play an essential role in the signaling of numerous cytokines that have been implicated in the pathogenesis of inflammatory diseases. Drugs that inhibit these kinases such as baricitinib, tofacitinib and ruxolitinib are thus plausible candidates for treatment of severe host inflammatory reactions to viral infection (Peterson et al. 2020, Richardson et al. 2020).

Literature References
PubMed ID Title Journal Year
20130243 Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms

Quintás-Cardama, A, Vaddi, K, Liu, P, Manshouri, T, Li, J, Scherle, PA, Caulder, E, Wen, X, Li, Y, Waeltz, P, Rupar, M, Burn, T, Lo, Y, Kelley, J, Covington, M, Shepard, S, Rodgers, JD, Haley, P, Kantarjian, H, Fridman, JS, Verstovsek, S

Blood 2010
24417533 Discovery and development of Janus kinase (JAK) inhibitors for inflammatory diseases

Clark, JD, Flanagan, ME, Telliez, JB

J. Med. Chem. 2014
23061660 Discovery of potent and selective pyrazolopyrimidine janus kinase 2 inhibitors

Hanan, EJ, van Abbema, A, Barrett, K, Blair, WS, Blaney, J, Chang, C, Eigenbrot, C, Flynn, S, Gibbons, P, Hurley, CA, Kenny, JR, Kulagowski, J, Lee, L, Magnuson, SR, Morris, C, Murray, J, Pastor, RM, Rawson, T, Siu, M, Ultsch, M, Zhou, A, Sampath, D, Lyssikatos, JP

J. Med. Chem. 2012
20363976 Selective inhibition of JAK1 and JAK2 is efficacious in rodent models of arthritis: preclinical characterization of INCB028050

Fridman, JS, Scherle, PA, Collins, R, Burn, TC, Li, Y, Li, J, Covington, MB, Thomas, B, Collier, P, Favata, MF, Wen, X, Shi, J, McGee, R, Haley, PJ, Shepard, S, Rodgers, JD, Yeleswaram, S, Hollis, G, Newton, RC, Metcalf, B, Friedman, SM, Vaddi, K

J. Immunol. 2010
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