SOS-mediated nucleotide exchange of RAS downstream of mutant PDGFR receptors

Stable Identifier
R-HSA-9672170
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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SOS-mediated nucleotide exchange of RAS downstream of mutant PDGFR receptors
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SOS-mediated exchange of GTP for GDP on RAS is predicted to be stimulated by gain-of-function PDGFRA mutants, based on the increased levels of phosphorylated MAPK3 and MAPK1 proteins (ERK1 and ERK2, respectively) (Heinrich et al, 2003; Corless et al, 2005; Ohashi et al, 2004; Velghe et al, 2014; reviewed in Corless et al, 2011; Roskoski, 2018).
Literature References
PubMed ID Title Journal Year
22089421 Gastrointestinal stromal tumours: origin and molecular oncology

Corless, CL, Barnett, CM, Heinrich, MC

Nat. Rev. Cancer 2011
29408302 The role of small molecule platelet-derived growth factor receptor (PDGFR) inhibitors in the treatment of neoplastic disorders

Roskoski, R

Pharmacol. Res. 2018
15221957 Different inhibitory effect of imatinib on phosphorylation of mitogen-activated protein kinase and Akt and on proliferation in cells expressing different types of mutant platelet-derived growth factor receptor-alpha

Ohashi, A, Kinoshita, K, Isozaki, K, Nishida, T, Shinomura, Y, Kitamura, Y, Hirota, S

Int. J. Cancer 2004
12522257 PDGFRA activating mutations in gastrointestinal stromal tumors

Heinrich, MC, Corless, CL, Duensing, A, McGreevey, L, Chen, CJ, Joseph, N, Singer, S, Griffith, DJ, Haley, A, Town, A, Demetri, GD, Fletcher, CD, Fletcher, JA

Science 2003
15928335 PDGFRA mutations in gastrointestinal stromal tumors: frequency, spectrum and in vitro sensitivity to imatinib

Corless, CL, Schroeder, A, Griffith, D, Town, A, McGreevey, L, Harrell, P, Shiraga, S, Bainbridge, T, Morich, J, Heinrich, MC

J. Clin. Oncol. 2005
23752188 PDGFRA alterations in cancer: characterization of a gain-of-function V536E transmembrane mutant as well as loss-of-function and passenger mutations

Velghe, AI, Van Cauwenberghe, S, Polyansky, AA, Chand, D, Montano-Almendras, CP, Charni, S, Hallberg, B, Essaghir, A, Demoulin, JB

Oncogene 2014
Participants
Input
Output
Participates
as an event of
Catalyst Activity

guanyl-nucleotide exchange factor activity of p-11Y PDGFR mutatnt receptors:GRB2:SOS1 [plasma membrane]

Physical Entity
p-11Y PDGFR mutatnt receptors:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activity
guanyl-nucleotide exchange factor activity (GO:0005085)
Normal reaction
SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Homo sapiens)
Functional status

Gain of function of p-11Y PDGFR mutatnt receptors:GRB2:SOS1 [plasma membrane]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
Mondo
Authored
Rothfels, K  (2020-02-25)
Reviewed
Ip, CKM  (2020-02-06)
Created
Rothfels, K  (2019-12-23)
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