SOS-mediated exchange of GTP for GDP on RAS is predicted to ...

created [InstanceEdit:9673754] Rothfels, Karen, 2020-01-08
dbId 9673733
displayName SOS-mediated exchange of GTP for GDP on RAS is predicted to ...
modified [InstanceEdit:9676121] Rothfels, Karen, 2020-02-08
schemaClass Summation
text SOS-mediated exchange of GTP for GDP on RAS is predicted to be stimulated by gain-of-function PDGFRA mutants, based on the increased levels of phosphorylated MAPK3 and MAPK1 proteins (ERK1 and ERK2, respectively) (Heinrich et al, 2003; Corless et al, 2005; Ohashi et al, 2004; Velghe et al, 2014; reviewed in Corless et al, 2011; Roskoski, 2018).
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