Reactome | imatinib-sensitive PDGFR mutants [plasma membrane]

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imatinib-sensitive PDGFR mutants [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9672127] Rothfels, Karen, 2019-12-23
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9672129
disease	[Disease:1500689] cancer
displayName	imatinib-sensitive PDGFR mutants [plasma membrane]
hasMember	[EntityWithAccessionedSequence:R-HSA-9671535] PDGFRA N659K [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9671557] PDGFRA V561D [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9671956] PDGFRA D842Y [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9671958] PDGFRA D846Y [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9671961] PDGFRA N848K [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9671974] PDGFRA Y849C [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9671545] PDGFRA D842_H845del [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9673603] PDGFRA T674I [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9673596] PDGFRA L629P [plasma membrane] - Homo sapiens
inDisease	true
literatureReference	[LiteratureReference:9671319] A precision therapy against cancers driven by KIT/PDGFRA mutations [LiteratureReference:9674274] Ripretinib (DCC-2618) Is a Switch Control Kinase Inhibitor of a Broad Spectrum of Oncogenic and Drug-Resistant KIT and PDGFRA Variants [LiteratureReference:9671911] PDGFRA mutations in gastrointestinal stromal tumors: frequency, spectrum and in vitro sensitivity to imatinib [LiteratureReference:9671429] Sorafenib inhibits many kinase mutations associated with drug-resistant gastrointestinal stromal tumors [LiteratureReference:9673492] A novel FIP1L1-PDGFRA mutant destabilizing the inactive conformation of the kinase domain in chronic eosinophilic leukemia/hypereosinophilic syndrome [LiteratureReference:9671886] Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies
maxDepth	2
memberOf	[DefinedSet:R-HSA-9674351] type II TKI sensitive PDGFR mutants [plasma membrane] - Homo sapiens
modified	[InstanceEdit:9674382] Rothfels, Karen, 2020-01-13
name	imatinib-sensitive PDGFR mutants
schemaClass	DefinedSet
species	[Species:48887] Homo sapiens
stId	R-HSA-9672129

Referrals

(hasMember)

[DefinedSet:R-HSA-9674351] type II TKI sensitive PDGFR mutants [plasma membrane]

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