Reactome | PDGFRA N659K [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9671534] Rothfels, Karen, 2019-12-19
crossReference	[DatabaseIdentifier:9671524] COSMIC:COSV57265972 [DatabaseIdentifier:9671548] COSMIC:COSV57264866 [DatabaseIdentifier:9671564] COSMIC:COSM18893
dbId	9671535
disease	[Disease:1500689] cancer [Disease:9661830] gastrointestinal stromal tumor [Disease:1996318] astrocytoma
displayName	PDGFRA N659K [plasma membrane]
endCoordinate	1089
hasModifiedResidue	[ReplacedResidue:9671541] L-asparagine 659 replaced with L-lysine
inDisease	true
memberOf	[CandidateSet:R-HSA-9674356] regorafenib-sensitive PDGFR mutants [plasma membrane] - Homo sapiens [DefinedSet:R-HSA-9674358] ripretinib sensitive PDGFR mutants [plasma membrane] - Homo sapiens [DefinedSet:R-HSA-9674352] sunitinib sensitive PDGFR mutants [plasma membrane] - Homo sapiens [DefinedSet:R-HSA-9672129] imatinib-sensitive PDGFR mutants [plasma membrane] - Homo sapiens [DefinedSet:R-HSA-9674344] avapritinib-sensitive PDGFR mutants [plasma membrane] - Homo sapiens
name	PDGFRA N659K Alpha platelet-derived growth factor receptor PGDS_HUMAN
referenceEntity	[ReferenceGeneProduct:61602] UniProt:P16234 PDGFRA
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9671535
startCoordinate	24

(hasMember)