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Schema
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BlackBoxEvent
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Entries
Phosphorylation of STATs downstream of KIT mutants
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authored
[InstanceEdit:9681395] Rothfels, Karen, 2020-04-01
catalystActivity
[CatalystActivity:9670410] protein tyrosine kinase activity of KIT mutant dimers:SFKs:p-JAK2:STATs [plasma membrane]
catalystActivityReference
[CatalystActivityReference:9643611] protein tyrosine kinase activity of p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] Lyn contributes to regulation of multiple Kit-dependent signaling pathways in murine bone marrow mast cells
category
omitted
compartment
[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created
[InstanceEdit:9670415] Rothfels, Karen, 2019-12-09
dbId
9670412
disease
[Disease:1500689] cancer
displayName
Phosphorylation of STATs downstream of KIT mutants
edited
[InstanceEdit:9686618] Rothfels, Karen, 2020-05-04
entityFunctionalStatus
[EntityFunctionalStatus:9670393] gain_of_function of KIT mutant dimers:SFKs:p-JAK2:STATs [plasma membrane]
eventOf
[Pathway:R-HSA-9670439] Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants - Homo sapiens
followingEvent
[Reaction:R-HSA-9670417] Dimerization of STATs downstream of KIT mutants - Homo sapiens
input
8 ×
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[Complex:R-HSA-9670379] KIT mutant dimers:SFKs:p-JAK2:STATs [plasma membrane]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:1433426] STAT protein recruitment and activation in c-Kit deletion mutants
[LiteratureReference:9670498] Signal transducer and activator of transcription 3 activation is required for Asp(816) mutant c-Kit-mediated cytokine-independent survival and proliferation in human leukemia cells
[LiteratureReference:9670475] Juxtamembrane mutant V560GKit is more sensitive to Imatinib (STI571) compared with wild-type c-kit whereas the kinase domain mutant D816VKit is resistant
[LiteratureReference:9669059] Activation mutations of human c-KIT resistant to imatinib mesylate are sensitive to the tyrosine kinase inhibitor PKC412
[LiteratureReference:9670489] M-COPA suppresses endolysosomal Kit-Akt oncogenic signalling through inhibiting the secretory pathway in neoplastic mast cells
[LiteratureReference:9670495] Oncogenic signaling by Kit tyrosine kinase occurs selectively on the Golgi apparatus in gastrointestinal stromal tumors
[LiteratureReference:9680303] Mechanisms of oncogenic KIT signal transduction in primary gastrointestinal stromal tumors (GISTs)
[LiteratureReference:9680307] KIT oncogenic signaling mechanisms in imatinib-resistant gastrointestinal stromal tumor: PI3-kinase/AKT is a crucial survival pathway
[LiteratureReference:1433411] Stat1 associates with c-kit and is activated in response to stem cell factor
[LiteratureReference:1433283] Signal transduction via the stem cell factor receptor/c-Kit
[LiteratureReference:9669245] Stem cell factor receptor/c-Kit: from basic science to clinical implications
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name
Phosphorylation of STATs downstream of KIT mutants
normalReaction
[BlackBoxEvent:R-HSA-1470009] Phosphorylation of STATs
output
8 ×
[SimpleEntity:R-ALL-29370] ADP [cytosol]
[Complex:R-HSA-9670369] p-JAK2:SFKs:p-KIT mutants:p-STATs [plasma membrane]
precedingEvent
[Reaction:R-HSA-9670416] Recruitment of STATs by KIT mutants - Homo sapiens
releaseDate
2020-06-10
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9678239] Serrano, César, 2020-03-13
[InstanceEdit:9678232] García-Valverde, Alfonso, 2020-03-13
[InstanceEdit:9678237] Pilco-Janeta, Daniel, 2020-03-13
schemaClass
BlackBoxEvent
species
[Species:48887] Homo sapiens
stId
R-HSA-9670412
summation
[Summation:9680608] Extracellular- , juxtamembrane- and kinase-domain mutants of...
Referrals
(hasEvent)
[Pathway:R-HSA-9670439] Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
(precedingEvent)
[Reaction:R-HSA-9670417] Dimerization of STATs downstream of KIT mutants
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