Phosphorylation of STATs downstream of KIT mutants

Stable Identifier
R-HSA-9670412
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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Phosphorylation of STATs downstream of KIT mutants
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Extracellular- , juxtamembrane- and kinase-domain mutants of KIT have been shown to activate the STAT pathway, as assessed by STAT phosphorylation. The biological relevance of each STAT isoform varies between tumor types (Brizzi et al, 1999; Ning et al, 2001; Frost et al, 2002; Growney et al, 2005; Hara et al, 2017; Obata et al, 2017; Duensing et al, 2004; Bauer et al, 2007; Deberry et al, 1997; Ronnstrand, 2004; reviewed in Lennartsson and Roonstrand, 2012).
Literature References
PubMed ID Title Journal Year
23073628 Stem cell factor receptor/c-Kit: from basic science to clinical implications

Lennartsson, J, Rönnstrand, L

Physiol. Rev. 2012
15007386 Mechanisms of oncogenic KIT signal transduction in primary gastrointestinal stromal tumors (GISTs)

Duensing, A, Medeiros, F, McConarty, B, Joseph, NE, Panigrahy, D, Singer, S, Fletcher, CD, Demetri, GD, Fletcher, JA

Oncogene 2004
28192400 Oncogenic signaling by Kit tyrosine kinase occurs selectively on the Golgi apparatus in gastrointestinal stromal tumors

Obata, Y, Horikawa, K, Takahashi, T, Akieda, Y, Tsujimoto, M, Fletcher, JA, Esumi, H, Nishida, T, Abe, R

Oncogene 2017
28403213 M-COPA suppresses endolysosomal Kit-Akt oncogenic signalling through inhibiting the secretory pathway in neoplastic mast cells

Hara, Y, Obata, Y, Horikawa, K, Tasaki, Y, Suzuki, K, Murata, T, Shiina, I, Abe, R

PLoS ONE 2017
12481435 Juxtamembrane mutant V560GKit is more sensitive to Imatinib (STI571) compared with wild-type c-kit whereas the kinase domain mutant D816VKit is resistant

Frost, MJ, Ferrao, PT, Hughes, TP, Ashman, LK

Mol. Cancer Ther. 2002
10358045 STAT protein recruitment and activation in c-Kit deletion mutants

Brizzi, MF, Dentelli, P, Rosso, A, Yarden, Y, Pegoraro, L

J Biol Chem 1999
15526160 Signal transduction via the stem cell factor receptor/c-Kit

Rönnstrand, L

Cell Mol Life Sci 2004
9355737 Stat1 associates with c-kit and is activated in response to stem cell factor

DeBerry, C, Mou, S, Linnekin, D

Biochem J 1997
11369651 Signal transducer and activator of transcription 3 activation is required for Asp(816) mutant c-Kit-mediated cytokine-independent survival and proliferation in human leukemia cells

Ning, ZQ, Li, J, Arceci, RJ

Blood 2001
17546049 KIT oncogenic signaling mechanisms in imatinib-resistant gastrointestinal stromal tumor: PI3-kinase/AKT is a crucial survival pathway

Bauer, S, Duensing, A, Demetri, GD, Fletcher, JA

Oncogene 2007
15790786 Activation mutations of human c-KIT resistant to imatinib mesylate are sensitive to the tyrosine kinase inhibitor PKC412

Growney, JD, Clark, JJ, Adelsperger, J, Stone, R, Fabbro, D, Griffin, JD, Gilliland, DG

Blood 2005
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of KIT mutant dimers:SFKs:p-JAK2:STATs [plasma membrane]

Physical Entity
KIT mutant dimers:SFKs:p-JAK2:STATs [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Normal reaction
Phosphorylation of STATs (Homo sapiens)
Functional status

Gain of function of KIT mutant dimers:SFKs:p-JAK2:STATs [plasma membrane]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
Mondo
Authored
Rothfels, K  (2020-04-01)
Reviewed
Serrano, C  (2020-03-13)
García-Valverde, A  (2020-03-13)
Pilco-Janeta, D  (2020-03-13)
Created
Rothfels, K  (2019-12-09)
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