Reactome | KIT W557_K558del [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

KIT W557_K558del [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-9670346] KIT W557_K558del dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9670346] KIT W557_K558del dimer [plasma membrane] - Homo sapiens
created	[InstanceEdit:9670342] Rothfels, Karen, 2019-12-09
crossReference	[DatabaseIdentifier:12020834] Mondo:0011719 [DatabaseIdentifier:9670318] COSMIC:COSV53029280 [DatabaseIdentifier:9670313] COSMIC:COSV55387046
dbId	9670343
disease	[Disease:9661830] gastrointestinal stromal tumor [Disease:1500689] cancer [Disease:9630839] acute myeloid leukemia
displayName	KIT W557_K558del [plasma membrane]
endCoordinate	976
hasModifiedResidue	[FragmentDeletionModification:9670333] Deletion of residues 557 to 558
inDisease	true
literatureReference	[LiteratureReference:9670319] Ponatinib inhibits polyclonal drug-resistant KIT oncoproteins and shows therapeutic potential in heavily pretreated gastrointestinal stromal tumor (GIST) patients [LiteratureReference:9669094] Complementary activity of tyrosine kinase inhibitors against secondary kit mutations in imatinib-resistant gastrointestinal stromal tumours
maxDepth	1
memberOf	[DefinedSet:R-HSA-9671494] avapritinib sensitive KIT mutants [plasma membrane] - Homo sapiens [CandidateSet:R-HSA-9669757] juxtamembrane domain KIT mutants [plasma membrane] - Homo sapiens
name	KIT W557_K558del Mast/stem cell growth factor receptor precursor KIT_HUMAN c-KIT
referenceEntity	[ReferenceGeneProduct:uniprot:P10721] UniProt:P10721 KIT
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9670343
startCoordinate	26

Referrals

(hasMember)	[CandidateSet:R-HSA-9669757] juxtamembrane domain KIT mutants [plasma membrane] [DefinedSet:R-HSA-9671494] avapritinib sensitive KIT mutants [plasma membrane]
(hasComponent)	[Complex:R-HSA-9670346] KIT W557_K558del dimer [plasma membrane]

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