Reactome | SPAST [cytosol]

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SPAST [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-9668517] LEM2D:ESCRT-III:IST1:CC2D1B:SPAST [nuclear envelope] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-9668405] SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin - Homo sapiens
created	[InstanceEdit:9668425] Orlic-Milacic, Marija, 2019-11-25
dbId	9668426
displayName	SPAST [cytosol]
endCoordinate	616
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-MMU-9668426] SPAST [cytosol] - Mus musculus [EntityWithAccessionedSequence:R-RNO-9668426] SPAST [cytosol] - Rattus norvegicus [EntityWithAccessionedSequence:R-CFA-9668426] SPAST [cytosol] - Canis familiaris [EntityWithAccessionedSequence:R-BTA-9668426] SPAST [cytosol] - Bos taurus [EntityWithAccessionedSequence:R-SSC-9668426] SPAST [cytosol] - Sus scrofa [EntityWithAccessionedSequence:R-SSC-9668426-2] SPAST [cytosol] - Sus scrofa [DefinedSet:R-SSC-9668426-3] Homologues of SPAST [cytosol] - Sus scrofa [EntityWithAccessionedSequence:R-DRE-9668426] SPAST [cytosol] - Danio rerio [EntityWithAccessionedSequence:R-XTR-9668426] SPAST [cytosol] - Xenopus tropicalis [EntityWithAccessionedSequence:R-GGA-9668426] SPAST [cytosol] - Gallus gallus [EntityWithAccessionedSequence:R-DME-9668426] SPAST [cytosol] - Drosophila melanogaster [EntityWithAccessionedSequence:R-CEL-9668426] SPAST [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-DDI-9668426] SPAST [cytosol] - Dictyostelium discoideum [GenomeEncodedEntity:R-SPO-9668426] Ghost homologue of SPAST [cytosol] - Schizosaccharomyces pombe [GenomeEncodedEntity:R-SCE-9668426] Ghost homologue of SPAST [cytosol] - Saccharomyces cerevisiae
maxDepth	1
name	SPAST Spastin fullName evidence="10 80"Spastin ecNumber evidence="10 37 40 45 48 50 65"5.6.1.1/ecNumber SPAST_HUMAN
producedByEvent	[Reaction:R-HSA-9668415] VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope - Homo sapiens
referenceEntity	[ReferenceGeneProduct:uniprot:Q9UBP0] UniProt:Q9UBP0 SPAST
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9668426
startCoordinate	1

Referrals

(input)	[Reaction:R-HSA-9668405] SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin
(activeUnit)	[CatalystActivity:9668531] microtubule severing ATPase activity of LEM2D:ESCRT-III:IST1:CC2D1B:SPAST [nuclear envelope]
(output)	[Reaction:R-HSA-9668415] VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope
(hasComponent)	[Complex:R-HSA-9668517] LEM2D:ESCRT-III:IST1:CC2D1B:SPAST [nuclear envelope]

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