Reactome | VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope

Schema > Reaction > Entries

VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope Show undefined attributes

authored	[InstanceEdit:9667932] Gerace, Larry, 2019-11-07
catalystActivity	[CatalystActivity:9668539] ATP hydrolysis activity of LEM2D:ESCRT-III:IST1:CC2D1B:SPAST:VPS4A [nuclear envelope]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:13231] nuclear envelope
created	[InstanceEdit:9668416] Orlic-Milacic, Marija, 2019-11-25
dbId	9668415
displayName	VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope
edited	[InstanceEdit:9668537] Orlic-Milacic, Marija, 2019-11-26
eventOf	[Pathway:R-HSA-9668328] Sealing of the nuclear envelope (NE) by ESCRT-III - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [Complex:R-HSA-9668535] LEM2D:ESCRT-III:IST1:CC2D1B:SPAST:VPS4A [nuclear envelope]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9668324] Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-HSA-9668424] CC2D1B [nuclear envelope] [EntityWithAccessionedSequence:R-HSA-917734] CHMP2A [cytosol] [EntityWithAccessionedSequence:R-HSA-917695] CHMP2B [cytosol] [EntityWithAccessionedSequence:R-HSA-917722] CHMP3 [cytosol] [EntityWithAccessionedSequence:R-HSA-917733] CHMP4A [cytosol] [EntityWithAccessionedSequence:R-HSA-917708] CHMP4B [cytosol] [EntityWithAccessionedSequence:R-HSA-917710] CHMP4C [cytosol] [EntityWithAccessionedSequence:R-HSA-917736] CHMP6 [cytosol] [EntityWithAccessionedSequence:R-HSA-917703] CHMP7 [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [EntityWithAccessionedSequence:R-HSA-9668516] IST1 [cytosol] [EntityWithAccessionedSequence:R-HSA-3067329] LEMD2 [nuclear envelope] [SimpleEntity:R-ALL-29372] Pi [cytosol] [EntityWithAccessionedSequence:R-HSA-9668426] SPAST [cytosol] [EntityWithAccessionedSequence:R-HSA-917732] VPS4A [cytosol]
precedingEvent	[Reaction:R-HSA-9668389] VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations - Homo sapiens
releaseDate	2020-03-17
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9668415
summation	[Summation:9668414] The AAA+ ATPase action of VPS4 causes reorganization/disasse...

Referrals

(hasEvent)

[Pathway:R-HSA-9668328] Sealing of the nuclear envelope (NE) by ESCRT-III

(precedingEvent)

[NegativePrecedingEvent:9764072] Futile Cycle: VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope
[NegativePrecedingEvent:9764064] Futile Cycle: VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope
[NegativePrecedingEvent:9764067] Futile Cycle: VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope
[NegativePrecedingEvent:9764074] Futile Cycle: VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope
[NegativePrecedingEvent:9764068] Futile Cycle: VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope
[NegativePrecedingEvent:9764073] Futile Cycle: VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope