Reactome | Sealing of the nuclear envelope (NE) by ESCRT-III

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Sealing of the nuclear envelope (NE) by ESCRT-III Show undefined attributes

authored	[InstanceEdit:9667932] Gerace, Larry, 2019-11-07
created	[InstanceEdit:9668337] Orlic-Milacic, Marija, 2019-11-25
dbId	9668328
displayName	Sealing of the nuclear envelope (NE) by ESCRT-III
edited	[InstanceEdit:9668537] Orlic-Milacic, Marija, 2019-11-26
eventOf	[Pathway:R-HSA-2995410] Nuclear Envelope (NE) Reassembly - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-9668335] CHMP7 binds LEMD2 - Homo sapiens [Reaction:R-HSA-9668398] CHMP7 binds CHMP4B, which recruits other subunits of the ESCRT-III complex - Homo sapiens [Reaction:R-HSA-9668395] CHMP7 binds CC2D1B - Homo sapiens [Reaction:R-HSA-9668405] SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin - Homo sapiens [Reaction:R-HSA-9668419] SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites - Homo sapiens [Reaction:R-HSA-9668389] VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations - Homo sapiens [Reaction:R-HSA-9668415] VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9667928] Mechanisms of nuclear pore complex assembly - two different ways of building one molecular machine [LiteratureReference:9668330] Reverse-topology membrane scission by the ESCRT proteins
maxDepth	2
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	Sealing of the nuclear envelope (NE) by ESCRT-III
orthologousEvent	[Pathway:R-BTA-9668328] Sealing of the nuclear envelope (NE) by ESCRT-III - Bos taurus [Pathway:R-SCE-9668328] Sealing of the nuclear envelope (NE) by ESCRT-III - Saccharomyces cerevisiae [Pathway:R-SPO-9668328] Sealing of the nuclear envelope (NE) by ESCRT-III - Schizosaccharomyces pombe [Pathway:R-DDI-9668328] Sealing of the nuclear envelope (NE) by ESCRT-III - Dictyostelium discoideum [Pathway:R-CEL-9668328] Sealing of the nuclear envelope (NE) by ESCRT-III - Caenorhabditis elegans [Pathway:R-DME-9668328] Sealing of the nuclear envelope (NE) by ESCRT-III - Drosophila melanogaster [Pathway:R-GGA-9668328] Sealing of the nuclear envelope (NE) by ESCRT-III - Gallus gallus [Pathway:R-XTR-9668328] Sealing of the nuclear envelope (NE) by ESCRT-III - Xenopus tropicalis [Pathway:R-DRE-9668328] Sealing of the nuclear envelope (NE) by ESCRT-III - Danio rerio [Pathway:R-SSC-9668328] Sealing of the nuclear envelope (NE) by ESCRT-III - Sus scrofa [Pathway:R-CFA-9668328] Sealing of the nuclear envelope (NE) by ESCRT-III - Canis familiaris [Pathway:R-RNO-9668328] Sealing of the nuclear envelope (NE) by ESCRT-III - Rattus norvegicus [Pathway:R-MMU-9668328] Sealing of the nuclear envelope (NE) by ESCRT-III - Mus musculus
releaseDate	2020-03-17
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9668328
summation	[Summation:9668333] During telophase, the double membrane of the reforming NE, w...

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(hasEvent)

[Pathway:R-HSA-2995410] Nuclear Envelope (NE) Reassembly

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