Reactome | ERBB2 T862A does not bind sapitinib

Schema > FailedReaction > Entries

authored	[InstanceEdit:9665122] Orlic-Milacic, Marija, 2019-10-30
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9665301] Orlic-Milacic, Marija, 2019-10-30
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9665304
disease	[Disease:1500689] cancer
displayName	ERBB2 T862A does not bind sapitinib
edited	[InstanceEdit:9665760] Orlic-Milacic, Marija, 2019-11-01
entityFunctionalStatus	[EntityFunctionalStatus:9665307] loss_of_function of ERBB2 T862A:ERBIN:HSP90:CDC37 [plasma membrane]
eventOf	[Pathway:R-HSA-9665244] Resistance of ERBB2 KD mutants to sapitinib - Homo sapiens
input	[Complex:R-HSA-9652386] ERBB2 T862A:ERBIN:HSP90:CDC37 [plasma membrane] [ChemicalDrug:R-ALL-9649894] Sapitinib [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9649445] High-Throughput Functional Evaluation of Variants of Unknown Significance in ERBB2
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ERBB2 T862A does not bind sapitinib
normalReaction	[Reaction:R-HSA-9652264] ERBB2 binds TKIs
releaseDate	2019-12-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9662685] Kancha, Rama Krishna, 2019-09-16
schemaClass	FailedReaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9665304
summation	[Summation:9665309] The following ERBB2 KD mutants are resistant to sapitinib:

(hasEvent)

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