ERBB2 T862A does not bind sapitinib

Stable Identifier
R-HSA-9665304
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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ERBB2 T862A does not bind sapitinib
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The following ERBB2 KD mutants are resistant to sapitinib:
ERBB2 T862A (Nagano et al. 2018);
Literature References
PubMed ID Title Journal Year
29967253 High-Throughput Functional Evaluation of Variants of Unknown Significance in ERBB2

Nagano, M, Kohsaka, S, Ueno, T, Kojima, S, Saka, K, Iwase, H, Kawazu, M, Mano, H

Clin. Cancer Res. 2018
Participants
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as an event of
Normal reaction
ERBB2 binds TKIs (Homo sapiens)
Functional status

Loss of function of ERBB2 T862A:ERBIN:HSP90:CDC37 [plasma membrane]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
Mondo
Authored
Orlic-Milacic, M  (2019-10-30)
Reviewed
Kancha, RK  (2019-09-16)
Created
Orlic-Milacic, M  (2019-10-30)
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