Reactome | SOH-C326-OGG1 S326C [nucleoplasm]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9658812] Orlic-Milacic, Marija, 2019-08-19
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9658815
disease	[Disease:1500689] cancer
displayName	SOH-C326-OGG1 S326C [nucleoplasm]
endCoordinate	345
hasModifiedResidue	[ReplacedResidue:9658768] L-serine 326 replaced with L-cysteine [ModifiedResidue:9658814] L-cysteine sulfenic acid at 326
inDisease	true
literatureReference	[LiteratureReference:9658804] hOGG1-Cys326 variant cells are hypersensitive to DNA repair inhibition by nitric oxide
maxDepth	1
memberOf	[CandidateSet:R-HSA-9657137] OGG1 mutants (FapyG hydrolysis) [nucleoplasm] - Homo sapiens [CandidateSet:R-HSA-9656300] OGG1 mutants (8oxoG hydrolysis) [nucleoplasm] - Homo sapiens
name	SOH-C326-OGG1 S326C
producedByEvent	[Reaction:R-HSA-9658813] OGG1 S326C is oxidized - Homo sapiens
referenceEntity	[ReferenceGeneProduct:uniprot:O15527] UniProt:O15527 OGG1
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9658815
startCoordinate	1

(hasMember)	[CandidateSet:R-HSA-9657137] OGG1 mutants (FapyG hydrolysis) [nucleoplasm] [CandidateSet:R-HSA-9656300] OGG1 mutants (8oxoG hydrolysis) [nucleoplasm]
(output)	[Reaction:R-HSA-9658813] OGG1 S326C is oxidized

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