Reactome | OGG1 S326C [nucleoplasm]

Schema > EntityWithAccessionedSequence > Entries

OGG1 S326C [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
consumedByEvent	[Reaction:R-HSA-9658813] OGG1 S326C is oxidized - Homo sapiens
created	[InstanceEdit:9658767] Orlic-Milacic, Marija, 2019-08-19
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9658769
disease	[Disease:1500689] cancer
displayName	OGG1 S326C [nucleoplasm]
endCoordinate	345
hasModifiedResidue	[ReplacedResidue:9658768] L-serine 326 replaced with L-cysteine
inDisease	true
literatureReference	[LiteratureReference:9658781] OGG1 Mutations and Risk of Female Breast Cancer: Meta-Analysis and Experimental Data [LiteratureReference:9658804] hOGG1-Cys326 variant cells are hypersensitive to DNA repair inhibition by nitric oxide [LiteratureReference:9658806] Repair of oxidative DNA damage is delayed in the Ser326Cys polymorphic variant of the base excision repair protein OGG1 [LiteratureReference:9658795] 8-Oxoguanine incision activity is impaired in lung tissues of NSCLC patients with the polymorphism of OGG1 and XRCC1 genes [LiteratureReference:9658782] Differential ability of polymorphic OGG1 proteins to suppress mutagenesis induced by 8-hydroxyguanine in human cell in vivo [LiteratureReference:9658809] DNA repair activity of 8-oxoguanine DNA glycosylase 1 (OGG1) in human lymphocytes is not dependent on genetic polymorphism Ser326/Cys326 [LiteratureReference:9658807] Excision of oxidatively damaged DNA bases by the human alpha-hOgg1 protein and the polymorphic alpha-hOgg1(Ser326Cys) protein which is frequently found in human populations
maxDepth	1
modified	[InstanceEdit:9658811] Orlic-Milacic, Marija, 2019-08-19
name	OGG1 S326C OGG1 Ser326Cys
referenceEntity	[ReferenceGeneProduct:uniprot:O15527] UniProt:O15527 OGG1
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9658769
startCoordinate	1

Referrals

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[Reaction:R-HSA-9658813] OGG1 S326C is oxidized