Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks

Stable Identifier
R-HSA-9657606
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Single mechanism MAP2K inhibitors bind to phosphorylated forms of MAP2K 1 and 2 and prevent their phosphorylation of MAPK proteins (Hatzivassiliou et al, 2013; reviewed in Samatar and Poulikakos, 2014).

Literature References
PubMed ID Title Journal Year
25435214 Targeting RAS-ERK signalling in cancer: promises and challenges

Samatar, AA, Poulikakos, PI

Nat Rev Drug Discov 2014
23934108 Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers

Hatzivassiliou, G, Haling, JR, Chen, H, Song, K, Price, S, Heald, R, Hewitt, JF, Zak, M, Peck, A, Orr, C, Merchant, M, Hoeflich, KP, Chan, J, Luoh, SM, Anderson, DJ, Ludlam, MJ, Wiesmann, C, Ultsch, M, Friedman, LS, Malek, S, Belvin, M

Nature 2013
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