Reactome | Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks

Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks

Stable Identifier

R-HSA-9657606

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks

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Single mechanism MAP2K inhibitors bind to phosphorylated forms of MAP2K 1 and 2 and prevent their phosphorylation of MAPK proteins (Hatzivassiliou et al, 2013; reviewed in Samatar and Poulikakos, 2014).

Literature References

PubMed ID	Title	Journal	Year
23934108	Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers Merchant, M, Haling, JR, Luoh, SM, Wiesmann, C, Price, S, Heald, R, Ultsch, M, Hatzivassiliou, G, Belvin, M, Peck, A, Ludlam, MJ, Zak, M, Hewitt, JF, Malek, S, Chan, J, Orr, C, Friedman, LS, Anderson, DJ, Hoeflich, KP, Song, K, Chen, H	Nature	2013
25435214	Targeting RAS-ERK signalling in cancer: promises and challenges Poulikakos, PI, Samatar, AA	Nat Rev Drug Discov	2014