Reactome | Drug-mediated inhibition of ERBB2 signaling

Schema > Pathway > Entries

created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10446126
displayName	Drug-mediated inhibition of ERBB2 signaling
eventOf	[Pathway:R-BTA-1227986] Signaling by ERBB2 - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-BTA-9652264] ERBB2 binds TKIs - Bos taurus
inferredFrom	[Pathway:R-HSA-9652282] Drug-mediated inhibition of ERBB2 signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Drug-mediated inhibition of ERBB2 signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48898] Bos taurus
stId	R-BTA-9652282
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-BTA-1227986] Signaling by ERBB2
(inferredTo)	[Pathway:R-HSA-9652282] Drug-mediated inhibition of ERBB2 signaling

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