Reactome | trastuzumab [extracellular region]

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trastuzumab [extracellular region] Show undefined attributes

compartment	[Compartment:984] extracellular region
componentOf	[Complex:R-HSA-9665468] ERBB2 ECD mutants:ERBIN:HSP90:CDC37:trastuzumab [plasma membrane] - Homo sapiens
consumedByEvent	[FailedReaction:R-HSA-9665232] Resistant ERBB2 KD mutants do not bind trastuzumab - Homo sapiens [Reaction:R-HSA-9665405] ERBB2 ECD mutants bind trastuzumab - Homo sapiens [Reaction:R-HSA-9649393] ERBB2 KD mutants bind trastuzumab - Homo sapiens [Reaction:R-HSA-9665696] ERBB2 TMD/JMD mutants bind trastuzumab - Homo sapiens [Reaction:R-HSA-9652277] ERBB2 binds trastuzumab - Homo sapiens
created	[InstanceEdit:9634464] Orlic-Milacic, Marija, 2019-01-10
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9634466
disease	[Disease:1500689] cancer
displayName	trastuzumab [extracellular region]
inDisease	true
maxDepth	1
name	trastuzumab herceptin D5v8 R-597
referenceEntity	[ReferenceTherapeutic:iuphar.ligand:5082] trastuzumab [Guide to Pharmacology:5082]
schemaClass	ProteinDrug
stId	R-ALL-9634466

Referrals

(input)	[FailedReaction:R-HSA-9665232] Resistant ERBB2 KD mutants do not bind trastuzumab [Reaction:R-HSA-9665405] ERBB2 ECD mutants bind trastuzumab [Reaction:R-HSA-9649393] ERBB2 KD mutants bind trastuzumab [Reaction:R-HSA-9665696] ERBB2 TMD/JMD mutants bind trastuzumab [Reaction:R-HSA-9652277] ERBB2 binds trastuzumab
(hasComponent)	[Complex:R-HSA-9665468] ERBB2 ECD mutants:ERBIN:HSP90:CDC37:trastuzumab [plasma membrane] [Complex:R-HSA-9649891] ERBB2 KD mutants (trastuzumab sensitive):trastuzumab [plasma membrane] [Complex:R-HSA-9665956] ERBB2 TMD/JMD mutants (trastuzumab):trastuzumab [plasma membrane] [Complex:R-RNO-9665221] ERBB2:trastuzumab [plasma membrane] [Complex:R-MMU-9665221] ERBB2:trastuzumab [plasma membrane] [Complex:R-DRE-9665221] ERBB2:trastuzumab [plasma membrane] [Complex:R-GGA-9665221] ERBB2:trastuzumab [plasma membrane] [Complex:R-CEL-9665221] ERBB2:trastuzumab [plasma membrane] [Complex:R-SSC-9665221] ERBB2:trastuzumab [plasma membrane] [Complex:R-CFA-9665221] ERBB2:trastuzumab [plasma membrane] [Complex:R-BTA-9665221] ERBB2:trastuzumab [plasma membrane] [Complex:R-DME-9665221] ERBB2:trastuzumab [plasma membrane] [Complex:R-HSA-9665221] ERBB2:trastuzumab [plasma membrane]
(activeUnit)	[NegativeRegulation:9665469] Negative regulation by 'ERBB2 ECD mutants:ERBIN:HSP90:CDC37:trastuzumab [plasma membrane]' [NegativeRegulation:9665328] Negative regulation by 'ERBB2 KD mutants (trastuzumab sensitive):trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane]' [NegativeRegulation:9652363] Negative regulation by 'ERBB2:trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane]'

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