Reactome | Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub

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Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub Show undefined attributes

authored	[InstanceEdit:9640596] Varusai, Thawfeek, 2019-04-02
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9641087] Varusai, Thawfeek, 2019-04-04
dbId	9641096
displayName	Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub
edited	[InstanceEdit:9667290] Varusai, Thawfeek, 2019-11-08
eventOf	[Pathway:R-HSA-9646399] Aggrephagy - Homo sapiens
followingEvent	[Reaction:R-HSA-9641111] Parkin transfers Ub to misfolded proteins - Homo sapiens
input	[DefinedSet:R-HSA-9641091] Misfolded Proteins [cytosol] [Complex:R-HSA-9641092] Ub:UBE2N:UBE2V1:PRKN [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9641088] Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub
orthologousEvent	[Reaction:R-PFA-9641096] Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub - Plasmodium falciparum [Reaction:R-DDI-9641096] Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub - Dictyostelium discoideum [Reaction:R-CEL-9641096] Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub - Caenorhabditis elegans [Reaction:R-DME-9641096] Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub - Drosophila melanogaster [Reaction:R-DRE-9641096] Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub - Danio rerio [Reaction:R-SSC-9641096] Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub - Sus scrofa [Reaction:R-BTA-9641096] Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub - Bos taurus [Reaction:R-CFA-9641096] Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub - Canis familiaris [Reaction:R-RNO-9641096] Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub - Rattus norvegicus [Reaction:R-MMU-9641096] Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub - Mus musculus
output	[Complex:R-HSA-9641099] Misfolded proteins:PRKN:UBE2N:UBE2V1:Ub [cytosol]
precedingEvent	[Reaction:R-HSA-9640114] Misfolded proteins translocate from cilium to cytosol - Homo sapiens [Reaction:R-HSA-9641089] Parkin binds Ub:UBE2N:UBE2V1 - Homo sapiens
releaseDate	2019-12-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9682018] Metzakopian, Emmanouil, 2019-05-24
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9641096
summation	[Summation:9641090] Stress factors damage and misfold cilia proteins, which are ...

Referrals

(hasEvent)	[Pathway:R-HSA-9646399] Aggrephagy
(precedingEvent)	[Reaction:R-HSA-9641111] Parkin transfers Ub to misfolded proteins