Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub

Stable Identifier
R-HSA-9641096
Type
Reaction [binding]
Species
Homo sapiens
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Stress factors damage and misfold cilia proteins, which are then translocated to the cytosol. Here, they are ubiquitinated via the UBE2N:UBE2V1:Parkin complex. The E3 ligase Parkin recruits the misfolded proteins to the E2 ubiquitin conjugation complex. This results in the polyubiquitination of misfolded proteins targeting them to degradation (Olzmann JA et al. 2007).

Literature References
PubMed ID Title Journal Year
17846173 Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6

Olzmann, JA, Li, L, Chudaev, MV, Chen, J, Perez, FA, Palmiter, RD, Chin, LS

J. Cell Biol. 2007
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