Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub

Stable Identifier
R-HSA-9641096
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub
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Stress factors damage and misfold cilia proteins, which are then translocated to the cytosol. Here, they are ubiquitinated via the UBE2N:UBE2V1:Parkin complex. The E3 ligase Parkin recruits the misfolded proteins to the E2 ubiquitin conjugation complex. This results in the polyubiquitination of misfolded proteins targeting them to degradation (Olzmann JA et al. 2007).
Literature References
PubMed ID Title Journal Year
17846173 Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6

Chin, LS, Palmiter, RD, Chudaev, MV, Perez, FA, Olzmann, JA, Chen, J, Li, L

J. Cell Biol. 2007
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Orthologous Events
Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Bos taurus)
Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Caenorhabditis elegans)
Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Canis familiaris)
Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Danio rerio)
Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Dictyostelium discoideum)
Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Drosophila melanogaster)
Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Gallus gallus)
Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Mus musculus)
Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Plasmodium falciparum)
Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Rattus norvegicus)
Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Schizosaccharomyces pombe)
Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Sus scrofa)
Authored
Varusai, TM  (2019-04-02)
Reviewed
Metzakopian, E  (2019-05-24)
Created
Varusai, TM  (2019-04-04)
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