v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine

Stable Identifier
Reaction [binding]
Homo sapiens
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The N-terminal domain of SLC38A9 bound to L-arginine interacts indirectly with the Ragulator complex via the Rag GTPases RRAGA and RRAGC (Wang et al. 2015, Rebsamen et al. 2015, Wyant et al. 2017, Shen and Sabatini 2018).
Literature References
PubMed ID Title Journal Year
30181260 Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms

Sabatini, DM, Shen, K

Proc. Natl. Acad. Sci. U.S.A. 2018
25567906 Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

Sabatini, DM, Wang, T, Zoncu, R, Jones, TD, Comb, W, Park, J, Straub, C, Wang, S, Shen, K, Tsun, ZY, Bar-Peled, L, Plovanich, ME, Chantranupong, L, Sabatini, BL, Kim, C, Yuan, ED, Wyant, GA, Wolfson, RL

Science 2015
25561175 SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1

Bigenzahn, JW, Huber, KV, Indiveri, C, Bennett, KL, Rebsamen, M, Superti-Furga, G, Kandasamy, RK, Rudashevskaya, EL, Snijder, B, Galluccio, M, Huber, LA, Heinz, LX, de Ara├║jo, ME, Pochini, L, Fauster, A, Filipek, PA, Bruckner, M, Scorzoni, S, Kraft, C, Stasyk, T

Nature 2015
29053970 mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient

Chen, WW, Sabatini, DM, Danai, LV, Abu-Remaileh, M, Wyant, GA, Vander Heiden, MG, Freinkman, E, Wolfson, RL

Cell 2017
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