Reactome | ATF4 and CEBPB,CEBPG bind the ASNS gene

ATF4 and CEBPB,CEBPG bind the ASNS gene

Stable Identifier

R-HSA-9635915

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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ATF4 and CEBPB or CEBPG bind a CEBP-ATF regulatory element (CARE) in the promoter of the ASNS gene (Siu et al 2001, Chen et al. 2004, inferred from mouse homologs). ATF4 binds rapidly during the first 2 hours after amino acid deprivation (Chen et al. 2004). ATF3 and CEBPB accumulate on the ASNS promoter more slowly and appear to correlate with decreasing transcription of ASNS (Chen et al. 2004). EIF2AK1 acts via ATF4 to activate transcription of ASNS in response to heme deficiency (inferred from mouse homologs).

Literature References

PubMed ID	Title	Journal	Year
11677247	CCAAT/enhancer-binding protein-beta is a mediator of the nutrient-sensing response pathway that activates the human asparagine synthetase gene Kilberg, MS, Zhong, C, Chen, C, Siu, F	J. Biol. Chem.	2001
15385533	Amino acid deprivation induces the transcription rate of the human asparagine synthetase gene through a timed program of expression and promoter binding of nutrient-responsive basic region/leucine zipper transcription factors as well as localized histone acetylation Kilberg, MS, Pan, YX, Chen, H, Dudenhausen, EE	J. Biol. Chem.	2004

Participants

Input

Output

ATF4:CEBPB,CEBPG:ASNS gene [nucleoplasm] (Homo sapiens)

Participates

as an event of

Inferred From

Atf4 and Cebpg bind the Asns gene (Mus musculus)

Authored

May, B (2019-02-09)

Reviewed

Staschke, KA (2019-11-20)

Chen, JJ (2019-10-22)

Bruhat, A (2019-09-15)

Created

May, B (2019-02-10)

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