Reactome | EIF2AK4 (GCN2) binds tRNA

Schema > Reaction > Entries

authored	[InstanceEdit:9633017] May, Bruce, 2018-12-27
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9633011] May, Bruce, 2018-12-27
dbId	9633005
displayName	EIF2AK4 (GCN2) binds tRNA
edited	[InstanceEdit:9633017] May, Bruce, 2018-12-27
eventOf	[Pathway:R-HSA-9633012] Response of EIF2AK4 (GCN2) to amino acid deficiency - Homo sapiens
followingEvent	[Reaction:R-HSA-9633742] EIF2AK4 (GCN2) dimer autophosphorylates - Homo sapiens
inferredFrom	[Reaction:R-MMU-9633481] Eif2ak4 binds tRNA - Mus musculus [Reaction:R-SCE-9633467] GCN2 binds tRNA - Saccharomyces cerevisiae
input	[Complex:R-HSA-9633014] EIF2AK4:GCN1:80S ribosome:mRNA [cytosol] [GenomeEncodedEntity:R-HSA-141679] tRNA [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:9640582] Activation of GCN2 by the ribosomal P-stalk
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	EIF2AK4 (GCN2) binds tRNA
output	[Complex:R-HSA-9633013] tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol]
releaseDate	2019-12-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9661246] Bruhat, Alain, 2019-09-15 [InstanceEdit:9668172] Staschke, Kirk A, 2019-11-20
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9633005
summation	[Summation:9635224] The histidyl-tRNA synthetase-like domain of EIF2AK4 (GCN2) b...

(hasEvent)	[Pathway:R-HSA-9633012] Response of EIF2AK4 (GCN2) to amino acid deficiency
(precedingEvent)	[Reaction:R-HSA-9633742] EIF2AK4 (GCN2) dimer autophosphorylates
(inferredTo)	[Reaction:R-MMU-9633481] Eif2ak4 binds tRNA [Reaction:R-SCE-9633467] GCN2 binds tRNA

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