Reactome | p16INK4A R80* [cytosol]

Schema > EntityWithAccessionedSequence > Entries

p16INK4A R80* [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9632589] Orlic-Milacic, Marija, 2018-12-19
crossReference	[DatabaseIdentifier:9632627] COSMIC:COSM13679 [DatabaseIdentifier:12021467] Mondo:0002527 [DatabaseIdentifier:9632628] COSMIC:COSV58686001
dbId	9632586
disease	[Disease:1500689] cancer [Disease:1614289] melanoma [Disease:2327993] hepatocellular carcinoma [Disease:8853117] lung adenocarcinoma [Disease:1500575] ovarian cancer [Disease:2328001] skin squamous cell carcinoma [Disease:1248679] head and neck squamous cell carcinoma [Disease:1493885] bladder carcinoma [Disease:9632622] keratoacanthoma [Disease:9632623] liposarcoma [Disease:2327989] bile duct carcinoma [Disease:9630851] gallbladder adenocarcinoma [Disease:9606370] chondrosarcoma [Disease:2362396] peripheral primitive neuroectodermal tumor [Disease:1500576] breast cancer [Disease:1996318] astrocytoma [Disease:2317358] endometrial cancer [Disease:2317476] acute lymphocytic leukemia [Disease:9630839] acute myeloid leukemia [Disease:9632617] diffuse large B-cell lymphoma [Disease:9632625] follicular lymphoma [Disease:9632624] peripheral T-cell lymphoma [Disease:1655483] renal clear cell carcinoma [Disease:9632629] papillary renal cell carcinoma [Disease:1248674] large intestine cancer [Disease:1500699] lung cancer [Disease:1981182] lung squamous cell carcinoma [Disease:1247848] non-small cell lung carcinoma [Disease:9632204] Barrett's esophagus [Disease:9632339] esophagus adenocarcinoma [Disease:9630862] esophagus squamous cell carcinoma [Disease:9630864] pancreatic ductal adenocarcinoma [Disease:2327994] penis carcinoma [Disease:1655494] prostate adenocarcinoma [Disease:1655480] salivary gland cancer [Disease:9632619] sebaceous carcinoma [Disease:2328199] basal cell carcinoma [Disease:3310977] small intestine carcinoma [Disease:1614291] rhabdomyosarcoma [Disease:6802256] thyroid carcinoma [Disease:9630843] oral squamous cell carcinoma [Disease:2328083] larynx cancer [Disease:9632616] oral mucosa leukoplakia [Disease:9632618] nasopharynx carcinoma [Disease:9632101] vulva squamous cell carcinoma
displayName	p16INK4A R80* [cytosol]
endCoordinate	79
hasModifiedResidue	[NonsenseMutation:9649366] Nonsense mutation at L-arginine 80
inDisease	true
literatureReference	[LiteratureReference:9632578] CDKN2A/p16 is inactivated in most melanoma cell lines [LiteratureReference:9632601] C-terminal domain of p16(INK4a) is adequate in inducing cell cycle arrest, growth inhibition and CDK4/6 interaction similar to the full length protein in HT-1080 fibrosarcoma cells
maxDepth	1
memberOf	[CandidateSet:R-HSA-9630804] p16INK4A LoF mutants (CDK4/6) [cytosol] - Homo sapiens
modified	[InstanceEdit:9649386] Orlic-Milacic, Marija, 2019-06-13
name	p16INK4A R80* p16INK4A R80TER p16INK4A Arg80TER p16INK4A Arg80* CDKN2A R80TER CDKN2A Arg80TER CDKN2A R80* CDKN2A Arg80*
referenceEntity	[ReferenceGeneProduct:uniprot:P42771] UniProt:P42771 CDKN2A
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9632586
startCoordinate	1
updateTrackers	[UpdateTracker:9900867] Update Tracker - [EntityWithAccessionedSequence:9632586] p16INK4A R80* [cytosol] - v70:[addHasModifiedResidue]

Referrals

(hasMember)	[CandidateSet:R-HSA-9630804] p16INK4A LoF mutants (CDK4/6) [cytosol]
(updatedInstance)	[UpdateTracker:9900867] Update Tracker - [EntityWithAccessionedSequence:9632586] p16INK4A R80* [cytosol] - v70:[addHasModifiedResidue]

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