Reactome | CSGALNACTs transfer GalNAc to CS chain

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CSGALNACTs transfer GalNAc to CS chain Show undefined attributes

authored	[InstanceEdit:1971508] Jassal, B, 2011-11-04
catalystActivity	[CatalystActivity:9632031] glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity of CSGALNACT [Golgi membrane]
category	transition
compartment	[Compartment:20699] Golgi membrane [Compartment:17963] Golgi lumen
created	[InstanceEdit:9632032] Jassal, Bijay, 2018-12-13
dbId	9632033
displayName	CSGALNACTs transfer GalNAc to CS chain
edited	[InstanceEdit:1971508] Jassal, B, 2011-11-04
eventOf	[Pathway:R-HSA-2022870] CS-GAG biosynthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-2018682] CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains - Homo sapiens [Reaction:R-HSA-1971483] CHST11,12,13,9 transfer sulfate to (4-)GalNAc - Homo sapiens
input	[DefinedSet:R-HSA-2064050] chondroitin(2)-core proteins [Golgi lumen] [SimpleEntity:R-ALL-735700] UDP-GalNAc [Golgi lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1971473] Molecular cloning and expression of human chondroitin N-acetylgalactosaminyltransferase: the key enzyme for chain initiation and elongation of chondroitin/dermatan sulfate on the protein linkage region tetrasaccharide shared by heparin/heparan sulfate [LiteratureReference:1971460] Enzymatic synthesis of chondroitin with a novel chondroitin sulfate N-acetylgalactosaminyltransferase that transfers N-acetylgalactosamine to glucuronic acid in initiation and elongation of chondroitin sulfate synthesis [LiteratureReference:9941057] Chondroitin Sulfate N-acetylgalactosaminyltransferase-1 (CSGalNAcT-1) Deficiency Results in a Mild Skeletal Dysplasia and Joint Laxity [LiteratureReference:9941190] Biosynthesis and function of chondroitin sulfate
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	CSGALNACTs transfer GalNAc to CS chain GalNAc is added to chondroitin
orthologousEvent	[Reaction:R-BTA-9632033] CSGALNACTs transfer GalNAc to CS chain - Bos taurus [Reaction:R-DME-9632033] CSGALNACTs transfer GalNAc to CS chain - Drosophila melanogaster [Reaction:R-GGA-9632033] CSGALNACTs transfer GalNAc to CS chain - Gallus gallus [Reaction:R-XTR-9632033] CSGALNACTs transfer GalNAc to CS chain - Xenopus tropicalis [Reaction:R-DRE-9632033] CSGALNACTs transfer GalNAc to CS chain - Danio rerio [Reaction:R-SSC-9632033] CSGALNACTs transfer GalNAc to CS chain - Sus scrofa [Reaction:R-CFA-9632033] CSGALNACTs transfer GalNAc to CS chain - Canis familiaris [Reaction:R-RNO-9632033] CSGALNACTs transfer GalNAc to CS chain - Rattus norvegicus [Reaction:R-MMU-9632033] CSGALNACTs transfer GalNAc to CS chain - Mus musculus
output	[DefinedSet:R-HSA-2064075] chondroitin(3)-core proteins [Golgi lumen] [SimpleEntity:R-ALL-425969] H+ [Golgi lumen] [SimpleEntity:R-ALL-205687] UDP [Golgi lumen]
precedingEvent	[Reaction:R-HSA-735702] SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP - Homo sapiens [Reaction:R-HSA-1971491] Chondroitin polymerase complex transfers GlcA to CS chain - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2172129] D'Eustachio, P, 2012-03-28 [InstanceEdit:9941989] D'Eustachio, Peter, 2025-03-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9632033
summation	[Summation:9941274] Chondroitin sulfate N-acetylgalactosaminyltransferases 1 and...
updateTrackers	[UpdateTracker:9953732] Update Tracker - [Reaction:9632033] CSGALNACTs transfer GalNAc to CS chain - v93:[add_removeLiteratureReference, add_removeSummation, removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9953732] Update Tracker - [Reaction:9632033] CSGALNACTs transfer GalNAc to CS chain - v93:[add_removeLiteratureReference, add_removeSummation, removeOutput]
(hasEvent)	[Pathway:R-HSA-2022870] CS-GAG biosynthesis
(precedingEvent)	[Reaction:R-HSA-2018682] CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains [Reaction:R-HSA-1971483] CHST11,12,13,9 transfer sulfate to (4-)GalNAc

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