Reactome | CHSY1 transfers GalNAc to chondroitin

CHSY1 transfers GalNAc to chondroitin

Stable Identifier

R-HSA-9632033

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane, Golgi lumen

Synonyms

GalNAc is added to chondroitin

ReviewStatus

5/5

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An N-acetylgalactosamine (GalNAc) moiety is added to the chondroitin chain by dual-activity enzymes, the chondroitin sulfate synthases 1-3 (CHSY1, CHPF and CHSY3 respectively) (Kitagawa et al. 2001, Yada et al. 2003, Yada et al. 2003b). They possess both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity, the latter activity used in this reaction. These three enzymes require divalent metals as cofactors, manganese producing the highest activities. The repeated disaccharide units of GlcA-GalNAc identify this glycosaminoglycan as chondroitin.

Literature References

PubMed ID	Title	Journal	Year
11514575	Molecular cloning and expression of a human chondroitin synthase Uyama, T, Kitagawa, H, Sugahara, K	J Biol Chem	2001
12761225	Chondroitin sulfate synthase-2. Molecular cloning and characterization of a novel human glycosyltransferase homologous to chondroitin sulfate glucuronyltransferase, which has dual enzymatic activities Yada, T, Kwon, YD, Kudo, T, Iwasaki, H, Gotoh, M, Watanabe, H, Go, M, Togayachi, A, Kimata, K, Sato, T, Kaseyama, H, Shionyu, M, Narimatsu, H, Kikuchi, N	J Biol Chem	2003
12907687	Chondroitin sulfate synthase-3. Molecular cloning and characterization Yada, T, Kwon, YD, Sato, T, Kudo, T, Iwasaki, H, Gotoh, M, Watanabe, H, Kaseyama, H, Narimatsu, H, Togayachi, A, Kikuchi, N, Kimata, K	J Biol Chem	2003