Reactome | CS-GAG biosynthesis

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CS-GAG biosynthesis Show undefined attributes

authored	[InstanceEdit:2022912] Jassal, B, 2011-12-01
created	[InstanceEdit:2022912] Jassal, B, 2011-12-01
dbId	2022870
diseasePathways	[Pathway:R-HSA-3595177] Defective CHSY1 causes TPBS - Homo sapiens [Pathway:R-HSA-3595172] Defective CHST3 causes SEDCJD - Homo sapiens
displayName	CS-GAG biosynthesis
edited	[InstanceEdit:2022912] Jassal, B, 2011-12-01
eventOf	[Pathway:R-HSA-1793185] Chondroitin sulfate/dermatan sulfate metabolism - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:161314] chondroitin sulfate proteoglycan biosynthetic process
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-1971482] CSGALNACTs transfer GalNAc to CS linker glycan - Homo sapiens [Reaction:R-HSA-1971491] Chondroitin polymerase complex transfers GlcA to CS chain - Homo sapiens [Reaction:R-HSA-1971487] Chondroitin polymerase complex transfers GalNAc to CS chain - Homo sapiens [Reaction:R-HSA-9632033] CSGALNACTs transfer GalNAc to CS chain - Homo sapiens [Reaction:R-HSA-1971483] CHST11,12,13,9 transfer sulfate to (4-)GalNAc - Homo sapiens [Reaction:R-HSA-2018659] CHST15 transfers sulfate to (6-)GalNAc-4-sulfate - Homo sapiens [Reaction:R-HSA-2018682] CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains - Homo sapiens [Reaction:R-HSA-9941305] UST transfers sulfate to (2-)GlcA-GalNAc-6-sulfate - Homo sapiens [BlackBoxEvent:R-HSA-2022911] CSPG is secreted - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2019-03-25
literatureReference	[LiteratureReference:1971426] Biosynthesis of chondroitin sulfate: from the early, precursor discoveries to nowadays, genetics approaches [LiteratureReference:1793181] Biosynthesis of chondroitin/dermatan sulfate [LiteratureReference:9941190] Biosynthesis and function of chondroitin sulfate [LiteratureReference:9941222] Chondroitin sulfate metabolism in the brain
maxDepth	2
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	CS-GAG biosynthesis Chondroitin sulfate biosynthesis
orthologousEvent	[Pathway:R-BTA-2022870] CS-GAG biosynthesis - Bos taurus [Pathway:R-MMU-2022870] CS-GAG biosynthesis - Mus musculus [Pathway:R-CFA-2022870] CS-GAG biosynthesis - Canis familiaris [Pathway:R-DME-2022870] CS-GAG biosynthesis - Drosophila melanogaster [Pathway:R-GGA-2022870] CS-GAG biosynthesis - Gallus gallus [Pathway:R-XTR-2022870] CS-GAG biosynthesis - Xenopus tropicalis [Pathway:R-DRE-2022870] CS-GAG biosynthesis - Danio rerio [Pathway:R-SSC-2022870] CS-GAG biosynthesis - Sus scrofa [Pathway:R-RNO-2022870] CS-GAG biosynthesis - Rattus norvegicus
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2172129] D'Eustachio, P, 2012-03-28 [InstanceEdit:9941989] D'Eustachio, Peter, 2025-03-12
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-2022870
summation	[Summation:2173802] Chondroitin sulfate (CS) glycosaminoglycan chains consist of...
updateTrackers	[UpdateTracker:9786119] Update Tracker - [Pathway:2022870] Chondroitin sulfate biosynthesis - v50:[updateContainedRLE] [UpdateTracker:9953726] Update Tracker - [Pathway:2022870] CS-GAG biosynthesis - v93:[add_removeHasEvent, modifyText, removeLiteratureReference] [UpdateTracker:9777994] Update Tracker - [Pathway:2022870] Chondroitin sulfate biosynthesis - v68:[addHasEvent] [UpdateTracker:9787009] Update Tracker - [Pathway:2022870] Chondroitin sulfate biosynthesis - v46:[modifyText, updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9786119] Update Tracker - [Pathway:2022870] Chondroitin sulfate biosynthesis - v50:[updateContainedRLE] [UpdateTracker:9953726] Update Tracker - [Pathway:2022870] CS-GAG biosynthesis - v93:[add_removeHasEvent, modifyText, removeLiteratureReference] [UpdateTracker:9777994] Update Tracker - [Pathway:2022870] Chondroitin sulfate biosynthesis - v68:[addHasEvent] [UpdateTracker:9787009] Update Tracker - [Pathway:2022870] Chondroitin sulfate biosynthesis - v46:[modifyText, updateContainedRLE]
(normalPathway)	[Pathway:R-HSA-3595177] Defective CHSY1 causes TPBS [Pathway:R-HSA-3595172] Defective CHST3 causes SEDCJD
(hasEncapsulatedEvent)	[Pathway:R-HSA-2024101] CS/DS degradation [Pathway:R-HSA-2022923] DS-GAG biosynthesis [Pathway:R-HSA-1971475] Glycosaminoglycan-protein linkage region biosynthesis
(hasEvent)	[Pathway:R-HSA-1793185] Chondroitin sulfate/dermatan sulfate metabolism

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