Reactome | Substrate:LAMP2a:HSP90 polymerizes

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Substrate:LAMP2a:HSP90 polymerizes Show undefined attributes

authored	[InstanceEdit:9637871] Varusai, Thawfeek, 2019-02-21
category	binding
compartment	[Compartment:161320] lysosomal lumen [Compartment:17938] lysosomal membrane
created	[InstanceEdit:9624150] Varusai, Thawfeek, 2018-10-08
dbId	9624158
displayName	Substrate:LAMP2a:HSP90 polymerizes
edited	[InstanceEdit:9667290] Varusai, Thawfeek, 2019-11-08
eventOf	[Pathway:R-HSA-9613829] Chaperone Mediated Autophagy - Homo sapiens
followingEvent	[Reaction:R-HSA-9625197] GFAP binds LAMP2a multimer - Homo sapiens
inferredFrom	[Polymerisation:R-RNO-9624154] Substrate:Lamp2a:Hsp90 polymerizes - Rattus norvegicus
input	[Complex:R-HSA-9622836] Substrate:LAMP2a:HSP90 [lysosomal membrane]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:9624149] Identification of regulators of chaperone-mediated autophagy [LiteratureReference:9622837] The chaperone-mediated autophagy receptor organizes in dynamic protein complexes at the lysosomal membrane
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Substrate:LAMP2a:HSP90 polymerizes
output	[Polymer:R-HSA-9624156] LAMP2a multimer complex [lysosomal membrane]
precedingEvent	[Reaction:R-HSA-9622831] Substrate:LAMP2a binds HSP90 - Homo sapiens
releaseDate	2019-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9637993] Metzakopian, Emmanouil, 2019-02-22
schemaClass	Polymerisation
species	[Species:48887] Homo sapiens
stId	R-HSA-9624158
summation	[Summation:9624152] Intracellular proteins are targeted for proteolytic degradat...

Referrals

(hasEvent)	[Pathway:R-HSA-9613829] Chaperone Mediated Autophagy
(precedingEvent)	[Reaction:R-HSA-9625197] GFAP binds LAMP2a multimer
(inferredTo)	[Polymerisation:R-RNO-9624154] Substrate:Lamp2a:Hsp90 polymerizes

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