Reactome | Activation of AMPK downstream of NMDARs

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Activation of AMPK downstream of NMDARs Show undefined attributes

authored	[InstanceEdit:9624342] Orlic-Milacic, Marija, 2018-10-10
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9619481] Orlic-Milacic, Marija, 2018-09-17
crossReference	[DatabaseIdentifier:12819703] BioModels Database:BIOMD0000000542
dbId	9619483
displayName	Activation of AMPK downstream of NMDARs
edited	[InstanceEdit:9628239] Orlic-Milacic, Marija, 2018-11-07
eventOf	[Pathway:R-HSA-438064] Post NMDA receptor activation events - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:645] chemical synaptic transmission
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-9619478] CAMKK2 phosphorylates AMPK - Homo sapiens [Reaction:R-HSA-9619515] AMPK phosphorylates MAPT - Homo sapiens [Reaction:R-HSA-9619542] AMPK negatively regulates binding of MAPT to microtubules - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9618904] The CAMKK2-AMPK kinase pathway mediates the synaptotoxic effects of A? oligomers through Tau phosphorylation
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	Activation of AMPK downstream of NMDARs
precedingEvent	[Reaction:R-HSA-9619355] CaMKK autophosphorylates in the cytosol - Homo sapiens
releaseDate	2018-12-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9627687] Yi, Feng, 2018-11-02 [InstanceEdit:9628437] Hansen, Kasper B, 2018-11-02
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9619483
summation	[Summation:9619482] Activation of NMDA receptors (NMDARs) leads to activation of...

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(hasEvent)

[Pathway:R-HSA-438064] Post NMDA receptor activation events

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